Biophysics Research Laboratory

Permanent URI for this collection

http://dspace.alquds.edu:4000/handle/20.500.12213/135

Overview

The biophysics lab has been established at Al-Quds University in 2005 with a generous fund from the DFG of the Federal Republic of Germany. The lab has supported several research students in the fields of physics and biology; several of whom are currently finishing their Doctorates degrees in Germany and the U.S. The research lab provides services to students and faculty members in the physics, biology, chemistry, and environmental science programs, in addition to an open cooperation with the college of medicine, pharmacy and the Nanotechnology center.

Our Team

Musa Abuteir

Ph.D Physics / Director

Sawsan Abusharkh

Ph.D. Biomedical physics

Saqer Darwish

Ph.D Physics

Husain Alsamamra

Ph.D Physics

Research Topics

Study of the interactions between different proteins (such as transthyretin, beta amyloid, Bovine Serum Albumin and Human serum albumin) and a variety of drugs and ligands such as pentobarbital, propofol, arginine, Procaine, Dopamine cholesterols and vitamins.

Design and develop drug delivery systems that could transport anti-cancer drugs to site of interest .
Synthesis and Characterization of nanoparticle drug delivery systems for different purposes.

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Now showing 1 - 5 of 16

Biophysical Interaction of Propylthiouracil with Human and Bovine Serum Albumins
(BMC, 2019-01-30) Alsamamra, Husain; Abuteir, Musa; Darwish, Saqer
The physical interaction of antithyroid drug, propylthiouracil was studied with bovine and human serum albumins through UV absorption and fluorescence spectroscopic techniques. The obtained values of the quenching constants were calculated by the Stern-Volmer equation are in the order of 1012 Lmol-1 s-1 indicating that both serum albumins were quenched by the drug in a static manner. The binding constants of the drug interaction with both HSA and BSA proteins are found to be relatively weak and are in the order of 103 M-1. The tryptophan residues of HSA and BSA are most perturbed by the binding process which was authenticated by the fluorescence spectra of both proteins in the presence of propylthiouracil. The importance behind this study is to clarify the mechanism of the interaction between propylthiouracil with HSA and BSA, as well as providing additional values in order to study drug-protein interaction which may facilitate the study of drug metabolism and transportation.
Spectroscopic Approach of Protein- Androgen Complexes: Study of Testosterone Interactions with Human Serum Albumin 'HSA'
(AL-Quds University, 2014-05-10) روان محمد خالد القواسمه; rawan mohammad khalid alqawasma; موسى أبو طير; د. محمود أبو حديد; No
Spectroscopic Study of the Interaction of Vitamin K_1(Phylloquinone) with Human Serum Albumin (HSA)
(AL-Quds University, 2013-02-24) علا فهد جميل حوراني; Ola Fahid Jameel Hoorani; موسى أبو طير; د. محمود أبو حديد; د. خولة قمحية; د. جمال غبون
Spectroscopic Investigations of Propofol and L-arginine Interactions with Beta-amyloid (1-40)
(AL-Quds University, 2014-02-01) شروق يوسف محمد عيايده; Shurook Yousef Mohammad Ayaydeh; صقر درويش; د. موسى ابو طير; جمال غضمون
Biological Samples Studies Using Broad Band Infrared Source
(AL-Quds University, 2017-12-20) اية علي ابراهيم ذويب; thweib ibrahim ali Aya; رشدي كتانه; Prof. Mohammad Abu Taha; Amin Leghrouz; Hisham Hidmi

Musa Abuteir

Sawsan Abusharkh

Saqer Darwish

Husain Alsamamra

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