Al-Quds University Digital Repository service

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Recent Submissions

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MICROBIOTA-TARGETED THERAPIES FOR PREVENTION OF COLORECTAL ADENOMA RECURRENCE AFTER POLYPECTOMY: A SYSTEMATIC REVIEW AND META-ANALYSIS
(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Layan Elayan; Mohammed Amer Kamel; Shankar Biswas; Yashasvi Srivastava; Ayman Hamadttu
Background: Colorectal cancer is the third most common malignancy worldwide, with approximately 1.9 million new cases annually. Despite effective removal of premalignant lesions, colorectal adenoma recurrence remains a major clinical challenge, affecting up to 60% of patients within five years after polypectomy. Current chemopreventive strategies are limited by modest efficacy or safety concerns. Aspirin benefits only a narrow population, while NSAIDs and nutritional supplements have shown no consistent benefit. Emerging evidence implicates gut microbiota dysbiosis in colorectal carcinogenesis, providing a strong biological rationale for microbiota-targeted interventions. Objectives: To conduct a systematic review and meta-analysis pooling probiotics, prebiotics, and microbiome-modulating agents under a unified framework to estimate their collective and class-specific efficacy in preventing colorectal adenoma recurrence following polypectomy, and to assess the certainty of evidence. Methods: This systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines and registered with PROSPERO (CRD420251247058). PubMed, Embase, CENTRAL, and Web of Science were searched from inception through November 2025 for randomized controlled trials evaluating microbiota-targeted therapies versus placebo or no treatment in adults post-polypectomy. The primary outcome was adenoma recurrence at surveillance colonoscopy. Risk ratios (RR) were pooled using random-effects models. Risk of bias was assessed using Cochrane RoB 2, and certainty of evidence was evaluated using GRADE.
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THE INTERPLAY OF SLEEP QUALITY AND SELF-EFFICACY ON MEDICAL STUDENT SYNDROME: A CROSS-SECTIONAL STUDY
(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Baraa Mohanned Nassar; Saeed Bakeer; Mohammed Amer Kamel; Ayman Khaled; Oday Shaar; Ibrahim Barham; Ahmad Hanani
Medical Student Syndrome (MSS) is a form of health-related anxiety in which medical students misattribute normal bodily sensations to diseases encountered during their studies. Its global prevalence ranges from 5% to 81%, making it a significant concern in medical education. Sleep disturbances affect 30–76% of medical students, impairing emotional regulation and increasing stress reactivity. Low self-efficacy—defined as an individual’s belief in their ability to execute goal-directed behaviors—has been consistently linked to heightened anxiety and depression. Despite evidence linking both sleep quality and self-efficacy to anxiety, no prior study has examined their combined relationship with MSS.
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PREVALENCE OF SUICIDAL RISK AND ITS ASSOCIATION WITH 2023 WAR EXPOSURE AMONG MEDICAL STUDENTS IN PALESTINE: A CROSS-SECTIONAL STUDY
(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Raghad S. Razem; Mohammad F. Zhour; Shahd T. Natsheh; Rama Dweik; Malak T. Etkaidek; Shams Shahateet; Israa Neal Mezyed; Saleem Hossam Helles; Mahmoud S. Alhaddad; Beesan Maraqa
Background: Medical students are particularly susceptible to psychological distress, which may be intensified in conflict settings. Following the 2023 war in Palestine, concerns have emerged regarding the compounded impact of trauma exposure and academic stress on suicidality. Objectives: The primary objective of this study was to assess the prevalence of suicidal risk among Palestinian medical students and examine its association with direct and indirect war-related exposure, as well as mental health factors. Methods: A cross-sectional study was conducted from October to December 2025 among medical students across universities in the West Bank and Gaza Strip. This abstract presents a preliminary analysis of a randomly selected subset (n = 510). Participants completed a structured bilingual questionnaire incorporating validated measures: the Suicide Behaviors Questionnaire-Revised (SBQ-R), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and a 13-item War Exposure Score.
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NON-INVASIVE NEUROMODULATION IN DRUG-RESISTANT PEDIATRIC EPILEPSY: A SCOPING REVIEW
(2026-05-12) Ayham Awad; Basil Abu Gheith; Ibrahim Zamara; Oday Hammad; Hadi Amro; Lama Mouharb; Osaid Tanbouz; Lara Ibrahim Ghannam
Background: Drug-resistant epilepsy (DRE) in childhood is associated with a substantial seizure burden, neurodevelopmental morbidity, and limited treatment options, particularly when surgery is not feasible. Non-invasive neuromodulation has emerged as a potential adjunctive strategy; however, the pediatric evidence base remains fragmented across modalities and study designs. Objectives: This study aimed to map the extent, characteristics, and reported outcomes of the published literature on non-invasive neuromodulation for pediatric DRE. Methods: This scoping review was conducted according to a pre-registered OSF protocol (Registration DOI: 10.17605/OSF.IO/Q2D5Y) and aligned with JBI guidance and PRISMA-ScR reporting standards. The review focused on children and adolescents aged 0–18 years with DRE treated using non-invasive neuromodulation techniques, including transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and transcutaneous vagus nerve stimulation (tVNS/taVNS). Primary studies with original clinical data were included. A total of 5,846 records were identified from PubMed, Scopus, and Web of Science; 1,560 duplicates were removed; 4,286 records were screened; 19 full texts were assessed; and 16 studies were included.
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KNOWLEDGE, ATTITUDES, AND DETERMINANTS OF CERVICAL CANCER SCREENING UPTAKE AMONG WOMEN IN PALESTINE: A POPULATION-BASED CROSS-SECTIONAL STUDY
(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Leen Ghanim; Abeer Barri; Haya Alsheqerat; Yasmin Bozia; Baraa Musa; Natalie Haj; Ibaa Mosleh; Shahed Bakhtan; Sura Manadre; Razan Massarwa; Al-Hareth Amro; Salah Aldeen Deeb
Cervical cancer is a malignant disease affecting the cervix and remains a major public health concern worldwide, particularly in low- and middle-income countries. It is primarily caused by persistent infection with high-risk human papillomavirus (HPV) and is largely preventable through vaccination and early screening. Despite the availability of effective screening methods such as the Pap smear test, many cases are still diagnosed at advanced stages due to the asymptomatic nature of early disease. In Palestine, cervical cancer is among the most common cancers affecting women, with relatively low incidence but concerning mortality rates. Limited access to screening services, low awareness, and sociocultural barriers contribute to reduced uptake of preventive practices.