• English
    • العربية
  • English 
    • English
    • العربية
  • Login
View Item 
  •   DSpace Home
  • AQU Research Network Clusters
  • AQU researchers publications
  • View Item
  •   DSpace Home
  • AQU Research Network Clusters
  • AQU researchers publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Study of Progesterone interaction with Human Serum Albumin: Spectroscopic approach

Thumbnail
View/Open
RES_119_JOURNAL_paper_2.pdf (2.471Mb)
Date
2011-01-17
Author
Abu Teir, M. M.
Ghithan, J. H.
Darwish, S. M.
Abu-Hadid, M. M.
Metadata
Show full item record
Abstract
The interaction between progesterone and human serum albumin has been investigated. This interaction was studied by UV-absorption and fluorescence spectroscopy. From spectral analysis progesterone showed a strong ability to quench the intrinsic fluorescence of HSA through a static quenching procedure. The binding constant (K) is estimated 6.56×102 M-1 at 293 K. FT-IR spectroscopy with Fourier self-deconvolution technique was used to determine HSA secondary structure and progesterone binding mechanisms. The observed spectral changes indicate the formation of H-bonding between progesterone and HSA molecules which can be related to the intensity decrease in the absorption band of α-helix relative to that of β-sheets.
URI
https://dspace.alquds.edu/handle/20.500.12213/890
Collections
  • AQU researchers publications [759]
  • Biophysics Research Laboratory [16]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

DSpace software copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback
Theme by 
Atmire NV