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Facile Synthesis of 2-Aminocyclobutenylphosphonates

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Rjoc0137-1.pdf (233.1Kb)
Date
2019-11-22
Author
Al Quntar, A. A. A.
Dweik, H.
Dembitsky, V.
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Abstract
The addition of various amines to diethyl 4-chlorobut-1-yn-1-ylphosphonate produced novel biologically potent substituted diethyl 2-aminocyclobut-1-en-1-ylphosphonates in 70–83% isolated yield. This regioselective reaction was carried out at room temperature in the absence of solvent and catalyst.
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https://dspace.alquds.edu/handle/20.500.12213/5719
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