Facile Synthesis of 2-Aminocyclobutenylphosphonates
Al Quntar, A. A. A.
Pleiades Publishing, Ltd
The addition of various amines to diethyl 4-chlorobut-1-yn-1-ylphosphonate produced novel biologically potent substituted diethyl 2-aminocyclobut-1-en-1-ylphosphonates in 70–83% isolated yield. This regioselective reaction was carried out at room temperature in the absence of solvent and catalyst.
vinylphosphonates , cyclobutenes , β-aminophosphonates , amine addition