Facile Synthesis of 2-Aminocyclobutenylphosphonates
Date
2019-11-22
Authors
Al Quntar, A. A. A.
Dweik, H.
Dembitsky, V.
Journal Title
Journal ISSN
Volume Title
Publisher
Pleiades Publishing, Ltd
Abstract
The addition of various amines to diethyl 4-chlorobut-1-yn-1-ylphosphonate produced novel
biologically potent substituted diethyl 2-aminocyclobut-1-en-1-ylphosphonates in 70–83% isolated yield. This
regioselective reaction was carried out at room temperature in the absence of solvent and catalyst.
Description
Keywords
vinylphosphonates , cyclobutenes , β-aminophosphonates , amine addition