Biomedicine
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- ItemSEX-SPECIFIC ASSOCIATION OF THE MAOA RS1137070 POLYMORPHISM WITH INTERNET ADDICTION SEVERITY AMONG AL-QUDS UNIVERSITY STUDENTS-PALESTINE: A CROSS-SECTIONAL STUDY(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Toqa Jawabreh; Abed Al-Majeed NasereddinThe rapid expansion of Internet usage has raised concerns about a possible association between Internet Addiction (IA) and a person's genetic predisposition. Studies indicate that the functional variation in the gene that encodes the enzyme monoamine oxidase A (MAOA) may affect the regulation of neurotransmitters involved with reward processing and impulse control, both of which relate to excessive Internet use. However, the role that MAOA polymorphisms play in the development of IA has not been well characterised; especially when it comes to identifying sex-specific differences regarding their effects. Objective: The goal of this study was to determine the associations between MAOA rs1137070 polymorphisms and IA severity, while considering demographic and academic characteristics and possible differences in the effect of the MAOA polymorphisms between males and females.
- ItemINVESTIGATING GENETIC POLYMORPHISMS IN TLR GENES AND THEIR ASSOCIATION WITH THE VARIATION OF CLINICAL OUTCOMES OF HELICOBACTER PYLORI INFECTION IN HEBRON DISTRICT(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Maya Musleh; AbdulMajeed Nasreldeen*Helicobacter pylori* is a Gram-negative, flagellated bacterium that colonizes the inner mucus layer of the stomach. It survives the acidic gastric environment and disrupts the protective mucosal lining through the production of virulence factors, leading to common but potentially severe infections such as chronic gastritis, peptic ulcer disease (PUD), and gastric cancer. Single-nucleotide polymorphisms (SNPs) in genes involved in immune regulation, particularly Toll-like receptors (TLRs), may influence host responses to *H. pylori* and contribute to variability in clinical outcomes. The global prevalence of *H. pylori* infection was estimated at 43.9% in 2022, while in the Eastern Mediterranean Region, including Palestine, prevalence ranges from 22% to 87.6%.
- ItemPRELIMINARY ANALYSIS OF PTPRS AND PTPRD GENETIC MARKERS IN ALZHEIMER’S PATIENTS IN PALESTINIAN NURSING HOMES: PILOT STUDY(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Sima Alnamoora; Mahmoud KhalidAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid β (Aβ) plaques, tau tangles, synaptic dysfunction, and cognitive decline. Genetic susceptibility factors strongly influence disease onset and progression, but population specific patterns remain underexplored, particularly in Middle Eastern cohorts. This study investigates single nucleotide polymorphisms (SNPs) within the protein tyrosine phosphatase receptor sigma (PTPRS) and delta (PTPRD) genes, key regulators of neuronal plasticity, signaling, and tau and Aβ homeostasis, in Palestinian AD patients residing in nursing homes. These genes were selected due to emerging evidence linking PTPRS to tau aggregation, synaptic integrity, and amyloid precursor protein processing, and PTPRD to neurofibrillary tangle accumulation and AD risk. A cross sectional genetic association design was employed. AD severity and neuropsychiatric symptoms were assessed via a caregiver completed questionnaire adapted from the Alzheimer's Questionnaire (2014) for the Palestinian context, which enabled staging of dementia severity and evaluation of symptoms including delusions, hallucinations, agitation, anxiety, and depression. Buccal swabs were collected from participants, and DNA was extracted, PCR amplified, and sequenced using Illumina NGS. Bioinformatic analysis was performed on the Galaxy platform, and statistical associations were evaluated in SPSS using chi square tests. Two SNPs were examined: rs560380 (PTPRD) and rs10415488 (PTPRS). While direct tau pathology assessment was not conducted, the risk alleles, rs10415488 T and rs560380 A, were selected based on prior evidence linking them to tau related pathogenesis and neurofibrillary tangle accumulation. According to Poirier et al. (2024), PTPRS serves as a novel marker for early tau pathology and synaptic integrity in Alzheimer's disease. Results revealed enrichment of these risk alleles in AD cases, with modest protective effects of the C alleles. However, statistical significance was not reached, largely due to the small sample size. Despite methodological constraints, this first Palestinian focused neurogenetic analysis highlights population specific risk alleles and demonstrates the potential utility of these SNPs as diagnostic markers for early tau pathology and synaptic integrity. The findings provide groundwork for future studies integrating molecular and clinical data into personalized AD diagnostics and therapeutics.
- ItemINVESTIGATING THE IMPACT OF HYPOXIA, HGF STIMULATION, AND SERUM STARVATION ON LINC00467 EXPRESSION IN MDA-MB-231 BREAST CANCER CELL LINE(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Amir Tarda; Ceazar Sobieh; Imad MatoukLong non-coding RNAs (lncRNAs) are key regulators of gene expression and play critical roles in cancer progression. Among them, LINC00467 has been identified as an oncogenic lncRNA associated with tumor growth, migration, and poor prognosis in multiple cancers, including breast cancer. However, its regulation under tumor microenvironment stress conditions—such as hypoxia, growth factor stimulation, and nutrient deprivation—remains insufficiently understood.
- ItemASSOCIATION BETWEEN FKBP5 SINGLE-NUCLEOTIDE POLYMORPHISMS AND GENETIC SUSCEPTIBILITY TO CONTINUOUS TRAUMATIC STRESS (CTS) IN PALESTINIANS LIVING UNDER SETTLER COLONIALISM(Deanship of Scientific Research - Al-Quds University, 2026-05-12) Christina Anastas; Abedelmajeed NasereddinContinuous traumatic stress (CTS) caused by persistent structural violence has massive and long-term psychological and biological consequences, yet its genetic basis is not well understood in affected populations. Palestinians are subjected to constant stress as a result of settler colonial violence, systematic racism, and oppression, all of which not only shape everyday life but also affect the human genome.