INVESTIGATING GENETIC POLYMORPHISMS IN TLR GENES AND THEIR ASSOCIATION WITH THE VARIATION OF CLINICAL OUTCOMES OF HELICOBACTER PYLORI INFECTION IN HEBRON DISTRICT
Date
2026-05-12
Authors
Maya Musleh
AbdulMajeed Nasreldeen
Journal Title
Journal ISSN
Volume Title
Publisher
Deanship of Scientific Research - Al-Quds University
Abstract
*Helicobacter pylori* is a Gram-negative, flagellated bacterium that colonizes the inner mucus layer of the stomach. It survives the acidic gastric environment and disrupts the protective mucosal lining through the production of virulence factors, leading to common but potentially severe infections such as chronic gastritis, peptic ulcer disease (PUD), and gastric cancer. Single-nucleotide polymorphisms (SNPs) in genes involved in immune regulation, particularly Toll-like receptors (TLRs), may influence host responses to *H. pylori* and contribute to variability in clinical outcomes. The global prevalence of *H. pylori* infection was estimated at 43.9% in 2022, while in the Eastern Mediterranean Region, including Palestine, prevalence ranges from 22% to 87.6%.