Antileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestine

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dc.contributor.authorHamarsheh, Omar
dc.contributor.authorAzmi, Kifaya
dc.contributor.authorAmro, Ahmad
dc.contributor.authorSchultheis, Martina
dc.contributor.authorAbdeen, Ziad
dc.contributor.authorFirdessa, Rebuma
dc.contributor.authorSawalha, Khaled
dc.contributor.authorAl-Rimawi, Fuad
dc.contributor.authorYaghmour, Reem
dc.contributor.authorMoll, Heidrun
dc.date.accessioned2019-03-31T15:15:30Z
dc.date.available2019-03-31T15:15:30Z
dc.date.issued2017-06-12
dc.description.abstractHerbal and traditional medicine is commonly and widely used in Palestine. There has been no ethno pharmacological study to document the usefulness of traditional or medicinal plants from Palestine against leishmaniasis, a spectrum of severe parasitic diseases that occur worldwide and is caused by protozoa of the genus Leishmania. The aim of the present study was to collect and analyze some of the traditionally used medicinal plants from Palestine against Leishmania major parasites that cause cutaneous leishmaniasis. Plant materials were collected during spring and summer of the year 2011, identified and the voucher numbers were kept at Al-Quds University Gardens (AQUG). The whole plant (except roots), flowers, fruits or seeds were collected, washed with distilled water, air dried in the shade for 20 days and then powdered in an electric grinder. For each plant species, alcoholic and dimethyl sulfoxide extracts were tested in vitro against L. major promastigotes and their antileishmanial activities were evaluated by Alamar Blue bioassay. Twenty plant species belonging to14 families were examined for their in vitro anti-parasitic effect against L. major. Among the total crude extracts tested; five were found to have various levels of activities (20%), some extracts having significant antileishmanial activity with IC50 values ranging from 8.83 to 100 μg/mL. The most active crude extracts were from the shoots of Artemisia inculta and Malva sylvestris with activity of 84.1%, IC50 = 8.8 μg/mL. And 90.1%, IC50 = 19.5 μg/mL respectively. The results demonstrate that the crude extracts of Artemisia inculta and Malva sylvestris showed promising antileishmanial activity, further and extensive studies should be carried out; particularly bio-guided fractionation to identify the active fraction and further chemical characterization of structureen_US
dc.description.sponsorshipThe authors gratefully thank the Deutscher Akademischer Austauschdienst (DAAD) and Zamallah program for providing travel grant. IMIB - Institute for Molecular Infection Biology, for providing support to validate this work at Würzburg University, financial support by the Deutsche Forschungsgemeinschaft (SFB 630) given To HM is gratefully acknowledgeden_US
dc.identifier.citationHamarsheh O, Azmi K, Amro A, Schultheis M, Abdeen Z, et al. (2017) Antileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestine. Ann Clin Cytol Pathol 3(4): 1065.en_US
dc.identifier.issn2475-9430
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4783
dc.language.isoenen_US
dc.titleAntileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestineen_US
dc.typeArticleen_US
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