Antileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestine

dc.contributor.author Hamarsheh, Omar
dc.contributor.author Azmi, Kifaya
dc.contributor.author Amro, Ahmad
dc.contributor.author Schultheis, Martina
dc.contributor.author Abdeen, Ziad
dc.contributor.author Firdessa, Rebuma
dc.contributor.author Sawalha, Khaled
dc.contributor.author Al-Rimawi, Fuad
dc.contributor.author Yaghmour, Reem
dc.contributor.author Moll, Heidrun
dc.date.accessioned 2019-03-31T15:15:30Z
dc.date.available 2019-03-31T15:15:30Z
dc.date.issued 2017-06-12
dc.description.abstract Herbal and traditional medicine is commonly and widely used in Palestine. There has been no ethno pharmacological study to document the usefulness of traditional or medicinal plants from Palestine against leishmaniasis, a spectrum of severe parasitic diseases that occur worldwide and is caused by protozoa of the genus Leishmania. The aim of the present study was to collect and analyze some of the traditionally used medicinal plants from Palestine against Leishmania major parasites that cause cutaneous leishmaniasis. Plant materials were collected during spring and summer of the year 2011, identified and the voucher numbers were kept at Al-Quds University Gardens (AQUG). The whole plant (except roots), flowers, fruits or seeds were collected, washed with distilled water, air dried in the shade for 20 days and then powdered in an electric grinder. For each plant species, alcoholic and dimethyl sulfoxide extracts were tested in vitro against L. major promastigotes and their antileishmanial activities were evaluated by Alamar Blue bioassay. Twenty plant species belonging to14 families were examined for their in vitro anti-parasitic effect against L. major. Among the total crude extracts tested; five were found to have various levels of activities (20%), some extracts having significant antileishmanial activity with IC50 values ranging from 8.83 to 100 μg/mL. The most active crude extracts were from the shoots of Artemisia inculta and Malva sylvestris with activity of 84.1%, IC50 = 8.8 μg/mL. And 90.1%, IC50 = 19.5 μg/mL respectively. The results demonstrate that the crude extracts of Artemisia inculta and Malva sylvestris showed promising antileishmanial activity, further and extensive studies should be carried out; particularly bio-guided fractionation to identify the active fraction and further chemical characterization of structure en_US
dc.description.sponsorship The authors gratefully thank the Deutscher Akademischer Austauschdienst (DAAD) and Zamallah program for providing travel grant. IMIB - Institute for Molecular Infection Biology, for providing support to validate this work at Würzburg University, financial support by the Deutsche Forschungsgemeinschaft (SFB 630) given To HM is gratefully acknowledged en_US
dc.identifier.citation Hamarsheh O, Azmi K, Amro A, Schultheis M, Abdeen Z, et al. (2017) Antileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestine. Ann Clin Cytol Pathol 3(4): 1065. en_US
dc.identifier.issn 2475-9430
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/4783
dc.language.iso en en_US
dc.title Antileishmanial Potential of Crude Plant Extracts Derived from Medicinal Plants in Palestine en_US
dc.type Article en_US
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