Preparation and characterization of carvedilolloaded poly(d,l) lactide nanoparticles/ microparticles as a sustained-release system

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dc.contributor.authorAssali, Mohyeddin
dc.contributor.authorZaid, Abdel Naser
dc.contributor.authorBani-Odeh, Majd
dc.contributor.authorFaroun, Maryam
dc.contributor.authorMuzaffar, Riham
dc.contributor.authorSawalha, Hassan
dc.date.accessioned2019-12-10T12:45:45Z
dc.date.available2019-12-10T12:45:45Z
dc.date.issued2017-02-08
dc.description.abstractCarvedilol poly(D,L)-lactide nanoparticles/microparticles were prepared. The size and morphology of the developed particles were optimized to study the carvedilol release profile by studying the effect of organic solvents and polymer amount through atomic force microscopy analysis. Spherical particles were obtained with a minimum size of 125 nm in the case of acetone and a maximum size of 970 nm in the case of dichloromethane affording microparticles formation. The interaction was confirmed by differential scanning calorimeter and Fourier transform infrared. The in vitro release profile of the multicompartment system (pure carvedilol, loaded nanoparticles and microparticles) has shown a sustained release with Korsmeyer–Peppas with T lag model.en_US
dc.description.sponsorshipAuthors acknowledge Cynthia Mizyed from the Language Center-An Najah National University for editing the article. Authors thank Dr Saed Khammash for the scientific discussion. Authors also acknowledge Dr Ramzi Shawahna for kinetic modeling analysis and thank the department of chemistry at An Najah National University for the FTIR analysis. Majd Bani-Odeh thanks An Najah National University for the teaching and research assistant scholarship.en_US
dc.identifier.citationMohyeddin Assali, Abdel Naser Zaid, Majd Bani-Odeh, Maryam Faroun, Riham Muzaffar & Hassan Sawalha (2017) Preparation and characterization of carvedilol-loaded poly(d,l) lactide nanoparticles/microparticles as a sustained-release system, International Journal of Polymeric Materials and Polymeric Biomaterials, 66:14, 717-725, DOI: 10.1080/00914037.2016.1263951en_US
dc.identifier.issn1563-535X
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5009
dc.language.isoenen_US
dc.publisherTaylor & Francis Groupen_US
dc.subjectAtomic force microscopyen_US
dc.subjecthydrophobic drugen_US
dc.subjectpoly(D,L)- lactide nanoparticle/ microparticlesen_US
dc.subjectsustainedrelease systemen_US
dc.titlePreparation and characterization of carvedilolloaded poly(d,l) lactide nanoparticles/ microparticles as a sustained-release systemen_US
dc.typeArticleen_US
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