Preparation and characterization of carvedilolloaded poly(d,l) lactide nanoparticles/ microparticles as a sustained-release system

Date
2017-02-08
Authors
Assali, Mohyeddin
Zaid, Abdel Naser
Bani-Odeh, Majd
Faroun, Maryam
Muzaffar, Riham
Sawalha, Hassan
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Group
Abstract
Carvedilol poly(D,L)-lactide nanoparticles/microparticles were prepared. The size and morphology of the developed particles were optimized to study the carvedilol release profile by studying the effect of organic solvents and polymer amount through atomic force microscopy analysis. Spherical particles were obtained with a minimum size of 125 nm in the case of acetone and a maximum size of 970 nm in the case of dichloromethane affording microparticles formation. The interaction was confirmed by differential scanning calorimeter and Fourier transform infrared. The in vitro release profile of the multicompartment system (pure carvedilol, loaded nanoparticles and microparticles) has shown a sustained release with Korsmeyer–Peppas with T lag model.
Description
Keywords
Atomic force microscopy, hydrophobic drug, poly(D,L)- lactide nanoparticle/ microparticles, sustainedrelease system
Citation
Mohyeddin Assali, Abdel Naser Zaid, Majd Bani-Odeh, Maryam Faroun, Riham Muzaffar & Hassan Sawalha (2017) Preparation and characterization of carvedilol-loaded poly(d,l) lactide nanoparticles/microparticles as a sustained-release system, International Journal of Polymeric Materials and Polymeric Biomaterials, 66:14, 717-725, DOI: 10.1080/00914037.2016.1263951