الفعالية المضادة للكائنات الدقيقه لدوائيْن أوليّيْن جديديْن مبتكريْن من مضادات البكتيريا؛ الأموكسيلين والسيفالكسين
Date
2015-06-02
Authors
ساميه صلاح الدين عبد الغني كرد
samia salahaldeen abdalgani kord
Journal Title
Journal ISSN
Volume Title
Publisher
AL-Quds University
جامعة القدس
جامعة القدس
Abstract
The two novel prodrugs of amoxicillin and cephalexin were synthesized to improve the
stability and bitter taste of their parent drugs. The in vitro susceptibility for both prodrugs
was determined against Escherichia coli, staphylococcus epidermidis, staphylococcus
aureus, Klebsiella pneumonia, streptococcus group A, streptococcus group B, and
compared to that of their parents.
The results revealed that both novel prodrugs have antibacterial activity on most bacterial
strains with about the same potency as their parent drugs, In addition, Klebsiella
pneumonia, and staphylococcus epidermidis showed resistance to both amoxicillin drug
and its prodrug. Since klebsiella is gram negative bacteria and staphylococcus
epidermidise is beta lactamase positive .
It is worth noting that those two novel prodrugs are among a small number of prodrugs
that have activity themselves before undergoing conversion via enzymatic or chemical
processes to their corresponding parent drugs. The novel prodrugs exhibit their
antibacterial activity against different types of bacterial strains due to the presence of beta
lactam ring in their structures.
In addition, it is expected that the novel two prodrugs will be much more stable in
aqueous media than their corresponding parent drugs due to the fact that the sensitive
amine group exists in the parent drugs was replaced with a more stable group, amide.
Description
Keywords
العلوم الصيدلانية , Pharmaceutical Sciences