الفعالية المضادة للكائنات الدقيقه  لدوائيْن أوليّيْن جديديْن مبتكريْن من مضادات البكتيريا؛ الأموكسيلين والسيفالكسين

ساميه صلاح الدين عبد الغني كرد; samia salahaldeen abdalgani kord

الفعالية المضادة للكائنات الدقيقه لدوائيْن أوليّيْن جديديْن مبتكريْن من مضادات البكتيريا؛ الأموكسيلين والسيفالكسين

dc.contributor.advisor	رفيق قرمان
dc.contributor.author	ساميه صلاح الدين عبد الغني كرد	ar
dc.contributor.author	samia salahaldeen abdalgani kord	en
dc.contributor.examiner	احمد عمرو
dc.contributor.examiner	حاتم سلامة
dc.date.accessioned	2018-10-07T11:30:54Z
dc.date.available	2018-10-07T11:30:54Z
dc.date.issued	2015-06-02
dc.description.abstract	The two novel prodrugs of amoxicillin and cephalexin were synthesized to improve the stability and bitter taste of their parent drugs. The in vitro susceptibility for both prodrugs was determined against Escherichia coli, staphylococcus epidermidis, staphylococcus aureus, Klebsiella pneumonia, streptococcus group A, streptococcus group B, and compared to that of their parents. The results revealed that both novel prodrugs have antibacterial activity on most bacterial strains with about the same potency as their parent drugs, In addition, Klebsiella pneumonia, and staphylococcus epidermidis showed resistance to both amoxicillin drug and its prodrug. Since klebsiella is gram negative bacteria and staphylococcus epidermidise is beta lactamase positive . It is worth noting that those two novel prodrugs are among a small number of prodrugs that have activity themselves before undergoing conversion via enzymatic or chemical processes to their corresponding parent drugs. The novel prodrugs exhibit their antibacterial activity against different types of bacterial strains due to the presence of beta lactam ring in their structures. In addition, it is expected that the novel two prodrugs will be much more stable in aqueous media than their corresponding parent drugs due to the fact that the sensitive amine group exists in the parent drugs was replaced with a more stable group, amide.	en
dc.identifier.other	21112814
dc.identifier.uri	https://dspace.alquds.edu/handle/20.500.12213/1327
dc.language.iso	en_US
dc.publisher	AL-Quds University	en
dc.publisher	جامعة القدس	ar
dc.subject	العلوم الصيدلانية	ar
dc.subject	Pharmaceutical Sciences	en
dc.subject.other	رسالة ماجستير	ar
dc.subject.other	دراسات عليا	ar
dc.subject.other	Higher Studies	en
dc.subject.other	Master Thesis	en
dc.title	الفعالية المضادة للكائنات الدقيقه لدوائيْن أوليّيْن جديديْن مبتكريْن من مضادات البكتيريا؛ الأموكسيلين والسيفالكسين	ar
dc.title	Antibacterial activity of Novel Prodrugs of Amoxicillin and Cephalexin	en
dc.type	Thesis

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