Oxetane-containing metabolites: origin, structures, and biological activities

Date
2019-01-04
Authors
Vil, Vera
Terent’ev, Alexander O.
Al Quntar, Abed Al Aziz
Gloriozova, Tatyana A.
Savidov, Nick
Dembitsky, Valery M.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer-Verlag GmbH Germany
Abstract
Cyclobutanes containing one oxygen atom in a molecule are called oxetane-containing compounds (OCC). More than 600 different OCC are found in nature; they are produced by microorganisms, and also found in marine invertebrates and algae. The greatest number of them is found in plants belonging to the genus Taxus. Oxetanes are high-energy oxygen-containing nonaromatic heterocycles that are of great interest as new potential pharmacophores with a significant spectrum of biological activities. The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, antiviral (arbovirus), and antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity dominate with confidence from 81 to 99%.
Description
Keywords
Oxetane, Cyclobutane, Microorganisms, Fungi, Algae, Invertebrates, Plant, Activities
Citation
Vil, V., Terent’ev, A.O., Al Quntar, A.A.A. et al. Appl Microbiol Biotechnol (2019) 103: 2449. https://doi.org/10.1007/s00253-018-09576-z