Topological modeling of antimycobacterial activity of 3-formyl rifamycin SV derivatives
Khadikar, Padmakar V.
The paper describes topological modeling of antimycobacterial activity of 3-formyl rifamycin SV derivatives using a large series of molecular vis-à-vis topological descriptors. For the set of 53 derivatives of 3-formyl rifamycin SV no one variable model is possible, however, in multiparametric regression excellent model is obtained for modeling the activity. The results are discussed using variety of statistical parameters.
Topological modeling , rifamycin , regression analysis , QSAR , topological index