Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review
Date
2025-02-22
Authors
Rayan R. Salahaldin
Mais E. Abubaker
Ghada M. Abdalqader
Anas R. Tuqan
Basel A. Zaben
Iba Barghouthi
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Abstract
Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting
with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis
is confirmed through histopathologic examination after curettage, and treatment typically involves stagedependent
chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding,
later diagnosed with choriocarcinoma. Despite initial single-agent chemotherapy, disease progression led to
uterine perforation and hemoperitoneum, requiring emergency surgery. Following recovery, multi-agent
chemotherapy resolved her symptoms. Choriocarcinoma’s rarity and varied presentation make diagnosis challenging,
with lung metastases common. Levels of b-hCG indicate treatment response, and prompt management
combining chemotherapy, monitoring, and surgery is crucial for positive outcomes.