Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis

dc.contributor.author Abu Ammar, Aiman
dc.contributor.author Nasereddin, Abed
dc.contributor.author Ereqat, Suheir
dc.contributor.author Dan-Goor, Mary
dc.contributor.author Jaffe, Charles L.
dc.contributor.author Zussman, Eyal
dc.contributor.author Abdeen, Ziad
dc.date.accessioned 2019-11-17T17:44:20Z
dc.date.available 2019-11-17T17:44:20Z
dc.date.issued 2018-11-27
dc.description.abstract Cutaneous leishmaniasis (CL) is an infectious, parasitic disease caused by the protozoan Leishmania. Amphotericin B (AMB) is a macrolide polyene antibiotic presenting potent antifungal and antileishmanial activity, but due to poor water solubility at physiological pH, side effects, and toxicity, its therapeutic efficiency is limited. In the present study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AMB were generated to reduce drug toxicity and facilitate localized delivery over a prolonged time. AMB NPs were characterized for particle size, zeta potential, polydispersity index, and degree of aggregation. In vitro assessments demonstrated its sustained activity against Leishmania major promastigotes and parasite-infected macrophages. A single intralesional administration to infected BALB/c mice revealed that AMB NPs were more effective than AMB deoxycholate in terms of reducing lesion area. Taken together, these findings suggest thatAMB NPs improve AMB delivery and can be used for local treatment of CL. en_US
dc.description.sponsorship This research was funded by the GIP program of the Deutsche Forschungsgemeinschaft (DFG) German Research Foundation. EZ wish to acknowledge the financial support of the RBNI-The Russell Berrie Nanotechnology Institute at the Technion. CLJ holds the Michael and Penny Feiwel Chair of Dermatology. en_US
dc.identifier.citation TY - JOUR AU - Abu Ammar, Aiman AU - Nasereddin, Abedelmajeed AU - Ereqat, Suheir AU - Dan-Goor, Mary AU - Jaffe, Charles AU - Zussman, Eyal AU - Abdeen, Ziad PY - 2018/11/27 SP - T1 - Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis. Full-text: https://rdcu.be/bb6AP VL - DO - 10.1007/s13346-018-00603-0 JO - Drug Delivery and Translational Research ER - en_US
dc.identifier.issn 2190-3948
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/4921
dc.language.iso en en_US
dc.publisher Springer en_US
dc.subject Amphotericin B en_US
dc.subject Nanoparticles en_US
dc.subject Sustained release en_US
dc.subject Cutaneous leishmaniasis en_US
dc.subject Topical therapy en_US
dc.title Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis en_US
dc.type Article en_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AbuAmmar2019_Article_AmphotericinB-loadedNanopartic.pdf
Size:
776.84 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: