Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis Abu Ammar, Aiman Nasereddin, Abed Ereqat, Suheir Dan-Goor, Mary Jaffe, Charles L. Zussman, Eyal Abdeen, Ziad 2019-11-17T17:44:20Z 2019-11-17T17:44:20Z 2018-11-27
dc.description.abstract Cutaneous leishmaniasis (CL) is an infectious, parasitic disease caused by the protozoan Leishmania. Amphotericin B (AMB) is a macrolide polyene antibiotic presenting potent antifungal and antileishmanial activity, but due to poor water solubility at physiological pH, side effects, and toxicity, its therapeutic efficiency is limited. In the present study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AMB were generated to reduce drug toxicity and facilitate localized delivery over a prolonged time. AMB NPs were characterized for particle size, zeta potential, polydispersity index, and degree of aggregation. In vitro assessments demonstrated its sustained activity against Leishmania major promastigotes and parasite-infected macrophages. A single intralesional administration to infected BALB/c mice revealed that AMB NPs were more effective than AMB deoxycholate in terms of reducing lesion area. Taken together, these findings suggest thatAMB NPs improve AMB delivery and can be used for local treatment of CL. en_US
dc.description.sponsorship This research was funded by the GIP program of the Deutsche Forschungsgemeinschaft (DFG) German Research Foundation. EZ wish to acknowledge the financial support of the RBNI-The Russell Berrie Nanotechnology Institute at the Technion. CLJ holds the Michael and Penny Feiwel Chair of Dermatology. en_US
dc.identifier.citation TY - JOUR AU - Abu Ammar, Aiman AU - Nasereddin, Abedelmajeed AU - Ereqat, Suheir AU - Dan-Goor, Mary AU - Jaffe, Charles AU - Zussman, Eyal AU - Abdeen, Ziad PY - 2018/11/27 SP - T1 - Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis. Full-text: VL - DO - 10.1007/s13346-018-00603-0 JO - Drug Delivery and Translational Research ER - en_US
dc.identifier.issn 2190-3948
dc.language.iso en en_US
dc.publisher Springer en_US
dc.subject Amphotericin B en_US
dc.subject Nanoparticles en_US
dc.subject Sustained release en_US
dc.subject Cutaneous leishmaniasis en_US
dc.subject Topical therapy en_US
dc.title Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis en_US
dc.type Article en_US
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