Total Antioxidant Status in Type 2 Diabetic Patients in Palestine
Date
2015-05-12
Authors
Kharroubi, Akram T.
Darwish, Hisham M.
Akkawi, Mutaz A.
Ashareef, Abdelkareem A.
Almasri, Zaher A.
Bader, Khaldoun A.
Khammash, Umaiyeh M.
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
The objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian
subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208
normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal bodymass index (BMI) levels (<25), 29% were overweight (≥25 to <30), and 61.2% were obese (≥30). The mean levels of TAS were significantly higher in diabetic compared to control subjects (2.18 versus 1.84mM Trolox, P = 0.001) and in hypertensive subjects compared to subjects with normal blood pressure (BP).Mean TAS levels were higher in obese compared to nonobese subjects (2.12 versus 1.85mMTrolox, P = 0.001).Mean TAS levels were similarly higher in subjects with high fasting plasma glucose (FPG) compared to normal FPG (2.19 versus 1.90mM Trolox) and high HbA1c (≥6.5%) compared to HbA1c < 6.5% (2.14 versus 1.91mMTrolox).Multivariate analysis revealed that only diabetic status (P = 0.032) and the level of education (P = 0.036) were significantly associated with TAS. In conclusion diabetic patients had 18.5% increase in TAS levels compared to control subjects.