Antibacterial Prodrugs to Overcome Bacterial Resistance
| dc.contributor.author | Jubeh, Buthaina | |
| dc.contributor.author | Breijyeh, Zeinab | |
| dc.contributor.author | Karaman, Rafik | |
| dc.date.accessioned | 2020-07-21T10:33:45Z | |
| dc.date.available | 2020-07-21T10:33:45Z | |
| dc.date.issued | 2020-03-28 | |
| dc.description.abstract | Bacterial resistance to present antibiotics is emerging at a high pace that makes the development of new treatments a must. At the same time, the development of novel antibiotics for resistant bacteria is a slow-paced process. Amid the massive need for new drug treatments to combat resistance, time and e ort preserving approaches, like the prodrug approach, are most needed. Prodrugs are pharmacologically inactive entities of active drugs that undergo biotransformation before eliciting their pharmacological e ects. A prodrug strategy can be used to revive drugs discarded due to a lack of appropriate pharmacokinetic and drug-like properties, or high host toxicity. A special advantage of the use of the prodrug approach in the era of bacterial resistance is targeting resistant bacteria by developing prodrugs that require bacterium-specific enzymes to release the active drug. In this article, we review the up-to-date implementation of prodrugs to develop medications that are active against drug-resistant bacteria. | en_US |
| dc.description.sponsorship | Acknowledgments: The authors would like to thank Al-Quds University-Scientific Research O ce for covering the publication fees for this review article. | en_US |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.uri | https://dspace.alquds.edu/handle/20.500.12213/5699 | |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.subject | prodrugs | en_US |
| dc.subject | biotransformation | en_US |
| dc.subject | targeting | en_US |
| dc.subject | β-lactam antibiotics | en_US |
| dc.subject | β-lactamases | en_US |
| dc.subject | pathogens | en_US |
| dc.subject | resistance | en_US |
| dc.title | Antibacterial Prodrugs to Overcome Bacterial Resistance | en_US |
| dc.type | Article | en_US |