Diclofenac Codrugs and Prodrugs-Three Decades of Design

Date
2015-06-08
Authors
Dweib, khuloud
Jumaa, Salma
Thawabteh, Ameen
Scrano, Laura
Bufo, Sabino A.
Mecca, Gennaro
Karaman, Rafik
Journal Title
Journal ISSN
Volume Title
Publisher
‎WJPPS,Dr. T Pal
Abstract
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without the involvement of enzymes. Prodrugs are designed to improve undesirable physicochemical and pharmacokinetic properties of their parent drugs. Non-steroidal anti-inflammatory (NSAIDs) drugs are among the most commonly used drugs for treatment of pain, inflammation and fever. Despite their frequent use, these agents suffer from gastrointestinal side effects that limit their use for those patients with gastrointestinal conditions. This mini review discusses the design, synthesis and pharmacological effects of prodrugs and codrugs of the non-steroidal anti-inflammatory (NSAIDs) Diclofenac sodium or potassium. It argues that the prodrug approach has the potential to eliminate Diclofenac associated gastrointestinal complications, increases its bioavailability and masks its bitter taste.
Description
Keywords
Non-steroidal anti-inflammatory drugs, gastrointestinal complications, enzymatic biotransformation, Diclofenac, Prodrugs, Predrugs
Citation