Recent Applications of Quantitative Structure-Activity Relationships in Drug Design
Date
2012-05-16
Authors
Deeb, Omar
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Abstract
One of the most important challenges that face medicinal chemists today is the design of
new drugs with improved properties and diminished side-effects for treating human
disease such as AIDS and others. Medicinal chemists began the process by taking a lead
structure and then finding analogs exhibiting the preferred biological activities. Next, they
used their experience and chemical insight to eventually choose a nominee analog for
further development. This process is difficult, expensive and took a long time. The
conventional methods of drug discovery are now being supplemented by shortest
approaches made possible by the accepting of the molecular processes involved in the
original disease. In this view, the preliminary point in drug design is the molecular target
which is receptor or enzyme in the body as an option of the existence of known lead
structure.