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dc.contributor.authorJubeh, Buthaina
dc.contributor.authorBreijyeh, Zeinab
dc.contributor.authorKaraman, Rafik
dc.date.accessioned2020-12-21T17:17:49Z
dc.date.available2020-12-21T17:17:49Z
dc.date.issued2020-06-23
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/6262
dc.description.abstractThe discovery of antibiotics has created a turning point in medical interventions to pathogenic infections, but unfortunately, each discovery was consistently followed by the emergence of resistance. The rise of multidrug-resistant bacteria has generated a great challenge to treat infections caused by bacteria with the available antibiotics. Today, research is active in finding new treatments for multidrug-resistant pathogens. In a step to guide the e orts, the WHO has published a list of the most dangerous bacteria that are resistant to current treatments and requires the development of new antibiotics for combating the resistance. Among the list are various Gram-positive bacteria that are responsible for serious healthcare and community-associated infections. Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and drug-resistant Streptococcus pneumoniae are of particular concern. The resistance of bacteria is an evolving phenomenon that arises from genetic mutations and/or acquired genomes. Thus, antimicrobial resistance demands continuous e orts to create strategies to combat this problem and optimize the use of antibiotics. This article aims to provide a review of the most critical resistant Gram-positive bacterial pathogens, their mechanisms of resistance, and the new treatments and approaches reported to circumvent this problem.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectresistanceen_US
dc.subjectGram-positiveen_US
dc.subjectMRSAen_US
dc.subject-lactamen_US
dc.subjectantimicrobialen_US
dc.subjectantibioticen_US
dc.subjectbacteriophageen_US
dc.subjectprobioticen_US
dc.titleResistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approachesen_US
dc.typeArticleen_US


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