Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches
dc.contributor.author | Jubeh, Buthaina | |
dc.contributor.author | Breijyeh, Zeinab | |
dc.contributor.author | Karaman, Rafik | |
dc.date.accessioned | 2020-12-21T17:17:49Z | |
dc.date.available | 2020-12-21T17:17:49Z | |
dc.date.issued | 2020-06-23 | |
dc.description.abstract | The discovery of antibiotics has created a turning point in medical interventions to pathogenic infections, but unfortunately, each discovery was consistently followed by the emergence of resistance. The rise of multidrug-resistant bacteria has generated a great challenge to treat infections caused by bacteria with the available antibiotics. Today, research is active in finding new treatments for multidrug-resistant pathogens. In a step to guide the e orts, the WHO has published a list of the most dangerous bacteria that are resistant to current treatments and requires the development of new antibiotics for combating the resistance. Among the list are various Gram-positive bacteria that are responsible for serious healthcare and community-associated infections. Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and drug-resistant Streptococcus pneumoniae are of particular concern. The resistance of bacteria is an evolving phenomenon that arises from genetic mutations and/or acquired genomes. Thus, antimicrobial resistance demands continuous e orts to create strategies to combat this problem and optimize the use of antibiotics. This article aims to provide a review of the most critical resistant Gram-positive bacterial pathogens, their mechanisms of resistance, and the new treatments and approaches reported to circumvent this problem. | en_US |
dc.identifier.uri | https://dspace.alquds.edu/handle/20.500.12213/6262 | |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | resistance | en_US |
dc.subject | Gram-positive | en_US |
dc.subject | MRSA | en_US |
dc.subject | β-lactam | en_US |
dc.subject | antimicrobial | en_US |
dc.subject | antibiotic | en_US |
dc.subject | bacteriophage | en_US |
dc.subject | probiotic | en_US |
dc.title | Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches | en_US |
dc.type | Article | en_US |