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dc.contributor.authorQabaha, Khaled
dc.contributor.authorAbu Ras, Sari
dc.contributor.authorAbbadi, Jehad
dc.contributor.authorAl-Rimawi, Fuad
dc.date.accessioned2020-02-23T19:55:27Z
dc.date.available2020-02-23T19:55:27Z
dc.date.issued2016-08-04
dc.identifier.citationTY - JOUR AU - Qabaha, Khaled AU - Ras, Sari AU - Abbadi, Jehad AU - Al-Rimawi, Fuad PY - 2016/08/12 SP - 1 EP - 6 T1 - Anti-inflammatory activity of Eucalyptus spp. and Pistascia lentiscus leaf extracts VL - 13 DO - 10.21010/ajtcam.v13i5.1 JO - African Journal of Traditional, Complementary, and Alternative Medicines ER -en_US
dc.identifier.issn0189-6016
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5078
dc.description.abstractBackground: Eucalyptus spp. and Pistascia lentiscus are among the Palestinian trees that are traditionally used in folkloric medicine in treating many diseases; leaves of which are thought to have anti-inflammatory, antibacterial and antioxidant effects. The goal of this study is to evaluate the in vitro inhibitory effect of Eucalyptus spp. and Pistascia lentiscus extracts on Lipopolysacaride (LPS)-induced Interlukin-6 (Il-6) and Tumor Necrosis Factor-α (TNF-α) by polymorphonuclear Cells (PMNCs). Materials and Methods: Polymorphonuclear cells were isolated from the whole blood using Histopaque (Ficol-1077) method and then cultured in an enriched Roswell Park Memorial Institute (RBMI) medium. Supernatants’ Interlukin-6 (IL-6) and Tumor Necrosis Factor (TNF-α) levels were determined 24 hour after LPS stimulation. HPLC was employed to determine the concentration of phenolic compounds in the extracts. The concentrations of TNF-α and IL-6 were compared using paired-samples t test. Results: Eucalyptus spp. and Pistascia lentiscus leaves extracts have shown significant reduction in the levels of both Il-6 and TNF-α Gallic acid; a strong anti-inflammatory agent was found to be the major phenolic compound in both leaf extracts. However, other antiinflammatory phenolic compounds were detected in Pitascia lentiscus extract including syringic acid and p-coumaric acid, while chlorogenic acid was detected in Eucalyptus spp. leaf extract. Conclusion: Reduction in the levels of Il-6 and TNF-α upon the effect of both Eucalyptus spp. and Pistascia lentiscus extract is an indication of their anti-inflammatory effects. Our results may also indicate that the observed anti-inflammatory effect of the above extracts may be due to the presence of gallic acid and other phenolic compounds.en_US
dc.language.isoenen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectEucalyptus sppen_US
dc.subjectPistascia lentiscusen_US
dc.subjectHPLCen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-6en_US
dc.titleAnti-inflammatory activity of eucalyptus spp. and pistascia lentiscus leaf extractsen_US
dc.typeArticleen_US


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