Preparation and characterization of carvedilolloaded poly(d,l) lactide nanoparticles/ microparticles as a sustained-release system
التاريخ
2017-02-08المؤلف
Assali, Mohyeddin
Zaid, Abdel Naser
Bani-Odeh, Majd
Faroun, Maryam
Muzaffar, Riham
Sawalha, Hassan
واصفات البيانات
عرض سجل المادة الكاملالخلاصة
Carvedilol poly(D,L)-lactide nanoparticles/microparticles were prepared. The size and morphology of the
developed particles were optimized to study the carvedilol release profile by studying the effect of
organic solvents and polymer amount through atomic force microscopy analysis. Spherical particles were
obtained with a minimum size of 125 nm in the case of acetone and a maximum size of 970 nm in the
case of dichloromethane affording microparticles formation. The interaction was confirmed by differential
scanning calorimeter and Fourier transform infrared. The in vitro release profile of the multicompartment
system (pure carvedilol, loaded nanoparticles and microparticles) has shown a sustained release with
Korsmeyer–Peppas with T lag model.