WW-Domain Containing Protein Roles in Breast Tumorigenesis
WW-Domain Containing Protein Roles in Breast Tumorigenesis
Date
2018-12-13
Authors
Jamous, Abrar
Salah, Zaidoun
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Abstract
Protein-protein interactions are key factors in executing protein function. These
interactions are mediated through different protein domains or modules. An important
domain found in many different types of proteins is WW domain. WW domain-containing
proteins were shown to be involved in many human diseases including cancer. Some
of these proteins function as either tumor suppressor genes or oncogenes, while others
show dual identity. Some of these proteins act on their own and alter the function(s)
of specific or multiple proteins implicated in cancer, others interact with their partners
to compose WW domain modular pathway. In this review, we discuss the role of
WW domain-containing proteins in breast tumorigenesis. We give examples of specific
WW domain containing proteins that play roles in breast tumorigenesis and explain
the mechanisms through which these proteins lead to breast cancer initiation and
progression. We discuss also the possibility of using these proteins as biomarkers or
therapeutic targets.
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Keywords
WW domain, WWOX, hippo pathway, E3 ligases, breast cancer
Citation
Jamous A and Salah Z (2018) WW-Domain Containing Protein Roles in Breast Tumorigenesis. Front. Oncol. 8:580. doi: 10.3389/fonc.2018.00580