مرض الالتهاب الكبدي الفيروسي (C )
رشدي رشاد رشدي رصرص
Rushdi Rashad Rushdi Rasras
Hepatitis C virus infection is a global public health problem. An estimated 3% of the world population is chronically infected with hepatitis C virus (HCV). It accounts for approximately 20% of cases of acute hepatitis and 70% of cases of chronic hepatitis. Chronic hepatitis C is a major cause of cirrhosis and hepatocellular carcinoma. Preliminary studies show that prevalence of HCV among blood donors in Gaza Strip is 0.3%. The main objective of this case control study is to define the risk factors of HCV among Gaza Strip, population. Variables studied include demographic status (sex, age, governorate, locality, maritual status, education level, occupation), and another risk factors for HCV transmission (travel abroad, health workers, blood transfusion, blood donation, having surgery, having insulin injection, having caesarian, having tattooing, visiting dentist, using un sterile injection, hemodialysis, using analgesics, making sure that barber changing the razor, practicing illegal sex, sharing family in teeth brush, sharing family with razor, sharing family with nail cutter). The study population is a sample of all reported positive cases in the records of bloodbanks and central laboratories in Gaza Strip for the year 2004. Two controls are chosen for each positive case, one from neighboring and the other from negative HCV-blood donors. The reported cases are coming from the five districts in Gaza Strip. At the time, controls are selected from the same localities. Number of cases reaches sixty eight (68) cases, and the number of controls is one hundred thirty six (136This step is followed by designing an entry model using computer software "Statistical Package for Social Sciences" (SPSS) where data was entered and analyzed. It is found that males are more exposed to HCV than females. According to age it is clear that people of 35 years and above has more chance to get HCV than those of less than 35 years. While there is no difference between villages, camps, and cities in chance of getting HCV. For education level, secondary level is at higher risk than elementary (OR= 3.47). It is also found that people who are working as employee and workers are more exposed to HCV than those who has no definite work (students, house keepers, police, un employee). In case of risk factors that could affect the chance of getting HCV in Gaza Strip. It is found that the main risk factors have statistically significance are: Travel abroad especially to Egypt, blood transfusion, having surgery, having tattooing, dentist visit for treatment, using un sterile injection. while risk factors which is not statistically significant in Gaza Strip were: blood donation, health organization workers, having insulin injection, having caesarian, using analgesics, hemodialysis, making shore that barber changing the razor, practicing illegal sex, sharingfamily with teeth brush, razor, and nail cutter. This study could be a model to define the risk factors associated with hepatitis C in a developing community as Gaza. Such study and similar studies will be a base for a successful intervention program to reduce prevalence rate of hepatitis C in Gaza, and in similar countries.).
الكيمياء الحيوية والاحياء الجزيئية , Biochemistry & Molecular Biology