THE ROLE OF CIRCULATING MICROBIAL DNA (CF-MBDNA) AS AN EARLY BIOMARKER OF CHRONIC INFLAMMATION IN LONG-STANDING DIABETES MELLITUS AND ITS ASSOCIATION WITH MICROVASCULAR COMPLICATIONS: A SYSTEMATIC REVIEW
Date
2026-05-12
Authors
Abdullah Talal Salem
Faisal Aljohani
Nuha Al Yousfi
Bashayr Alkuhayli
Ahmed Isa
Arwa Hammouda
Yara Alamri
Abdullah Almohamad Almustafa
Alaa Habashi
Siraj Fakiha
Journal Title
Journal ISSN
Volume Title
Publisher
Deanship of Scientific Research - Al-Quds University
Abstract
Background: Circulating microbial DNA (cf-mbDNA) and related cell-free DNA (cfDNA) fragments have emerged as novel biomarkers reflecting metabolic stress, inflammation, and vascular injury in diabetes mellitus (DM). This systematic review aimed to synthesize current evidence on their diagnostic potential for detecting chronic inflammation and microvascular complications in long-standing diabetes. Study Purpose/
Objectives: The role of circulating microbial DNA (cf-mbDNA) as an early biomarker of chronic inflammation in long-standing diabetes mellitus and its association with microvascular complications: A systematic review
Methods: Following PRISMA 2020 guidelines, ten peer-reviewed studies published between 2010 and 2025 were systematically analyzed across multiple databases. Eligible studies assessed cfDNA or cf-mbDNA in plasma or serum samples from patients with type 1 or type 2 diabetes, investigating associations with inflammatory and vascular markers.