Biomedical Sciences

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https://dspace.alquds.edu/handle/20.500.12213/9351

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Browsing Biomedical Sciences by Title

Now showing 1 - 6 of 6
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    Antidepressants: New Hypothetical Interactions to Increase Their Efficiency
    (Deanship of Research/ Al-Quds University, 2024-04-01) Hanan Atari; Ghadeer Jamal; Dena Jaffal; Noor Alhalaby; Rayhana Aljana Jboor; Mohammad Qabajah
    Depression is a prevalent disorder that stems from an imbalance in brain chemistry, particularly involving neurotransmitters. It is commonly treated with antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), which work by inhibiting the reuptake of serotonin. Paroxetine is one of the most commonly used SSRIs; however, it is associated with side effects on both thyroid and sex hormones. The objective of this study is to identify an alternative compound or drug to paroxetine that offers fewer side effects.
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    Assessment of Antioxidant, Antimicrobial, and Anticancer Activity of Olea europaea Leaves Extracts and Its Effects on Apoptotic Genes
    (Deanship of Research/ Al-Quds University, 2024-04-01) Zain Wael Shweiky; Mahmoud Khalid
    The olive tree (Olea europaea) is a rich source of phenolic compounds, known for their health benefits. These compounds, particularly abundant in Palestinian olive leaves, have been shown to possess antioxidant and antimicrobial properties. This study explores the potential of olive leaf extracts to target cancer by investigating their effects on genes involved in the critical process of apoptosis, or programmed cell death.
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    Identification of Toxoplasma Gondii Epitopes Using Phage Display Libraries for Serodiagnostic Purposes
    (Deanship of Research/ Al-Quds University, 2024-04-01) Deena Sayes; Ibrahim Abbasi
    Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii that can infect humans and animals. Currently, the diagnosis of toxoplasmosis can be performed through various methods, including serological and molecular methods. However, while molecular methods are highly sensitive and specific, they require highly specialized laboratory equipment and high BSL (biosafety levels), which may not be readily available in many settings. Moreover, molecular methods require the use of genetic material, which can pose a risk of infection for laboratory personnel. On the other hand, serological methods are more accessible and affordable, and they can detect the presence of antibodies against T. gondii, which indicates a past or current infection. Additionally, serological methods can identify specific T. gondii antigens or epitopes, which can be used to develop diagnostic tools without the need for live parasites. Thus, there is a need to explore the potential of serological methods for the diagnosis of toxoplasmosis and their potential applications in the development of safer and easier diagnostic tools. The identification of specific epitopes using phage display libraries can improve the specificity and sensitivity of diagnostic assays for T. gondii infection in cats and humans. Objectives: the research aims to identify specific epitopes that can be used in the diagnosis of Toxoplasma gondii infection using M13 phage display libraries, and then to analyze the sequences of the isolated phages using next generation DNA sequencing and bioinformatics tools.
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    Phenotypic and genotypic characterization of Palestinian patients with neuronal ceroid lipofuscinosis: A report of 5 new individuals and novel pathogenic variant
    (Deanship of Research/ Al-Quds University, 2024-04-01) Malik Al-Tubjah; Huthaifa Haj Ahmad; Fida’ Al-Hijawi; Motee Ashhab; Reham Khalaf-Nazzal
    Neuronal ceroid lipofuscinoses (NCLs) are a group of ultrarare inherited neurodegenerative disorders characterized by consistent clinical features and pathophysiology. Pathogenic variants in several genes were established to be causative for NCL. These genes encode various types of proteins, including lysosomal, cytoplasmic, and transmembrane proteins involved in lipid and protein trafficking, endocytosis, and lysosomal transport. Loss of function variants in NCL genes result in the buildup of autofluorescent lipoprotein aggregates, known as ceroid lipofuscin, in neurons and other cells. This accumulation leads to progressive psychomotor decline, visual impairment, and ultimately, premature death.
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    The Antibacterial, Antioxidant, and Anticancer Activity of Sage and Nutmeg Ethanolic Extract
    (Deanship of Research/ Al-Quds University, 2024-04-01) Sondos Karshan; Fuad Al-Rimawi
    Alternative cancer and bacterial infection treatments are desperately needed, as worries about the declining effectiveness and side effects of traditional drugs grow. To aid in the creation of new medications and preventative measures. the study attempts to confirm the therapeutic potential of nutmeg (Myristica fragrant) and sage (Salvia officinalis) extracts in addressing these health issues.
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    Using Bioinformatics Analysis to Suggest Combating Anti- venom against the Palestinian Viper Snake
    (Deanship of Research/ Al-Quds University, 2024-04-01) Hammam Rabai; Zina Omar; Maysam Khateeb; Jawaher Shojaei; Mohammad qabaja
    Palestine viper venom is known to possess potent toxic effects and poses a significant risk to human health. Developing effective anti-venom is crucial for mitigating the consequences of envenomation. In this study, we aimed to propose anti-venom against Palestine viper venom through bioinformatics analysis and tools.