(Al-Quds University, Deanship of Scientific Research, 2022-05-11) Amani Bashar Ahmed; Rahmeh Y. Natsheh; Oday M. Abushalbaq; Hussain Y. Khdour; Mahmud A. Sehwail; Mohmmad M. Herzallah
Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders in Palestine. It manifests as symptoms of depressed mood and loss of interest in daily life activities. The “Cytokine Hypothesis of Depression” argues that MDD results from an imbalance between pro- and anti-inflammatory cytokines. Only 30% of patients with MDD respond to treatment with SSRI antidepressants.