Cytokine Profiles Could a Priori Predict Response to SSRIs in Medication-Naïve Patients with Major Depressive Disorder
Date
2022-05-11
Authors
Amani Bashar Ahmed
Rahmeh Y. Natsheh
Oday M. Abushalbaq
Hussain Y. Khdour
Mahmud A. Sehwail
Mohmmad M. Herzallah
Journal Title
Journal ISSN
Volume Title
Publisher
Al-Quds University, Deanship of Scientific Research
Abstract
Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders in Palestine. It manifests as symptoms of depressed mood and loss of interest in daily life activities. The “Cytokine Hypothesis of Depression” argues that MDD results from an imbalance between pro- and anti-inflammatory cytokines. Only 30% of patients with MDD respond to treatment with SSRI antidepressants.