Neuroscience

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https://hdl.handle.net/20.500.12213/6536

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Browsing Neuroscience by Author "Mahmud A. Sehwail"

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    Cytokine Profiles Could a Priori Predict Response to SSRIs in Medication-Naïve Patients with Major Depressive Disorder
    (Al-Quds University, Deanship of Scientific Research, 2022-05-11) Amani Bashar Ahmed; Rahmeh Y. Natsheh; Oday M. Abushalbaq; Hussain Y. Khdour; Mahmud A. Sehwail; Mohmmad M. Herzallah
    Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders in Palestine. It manifests as symptoms of depressed mood and loss of interest in daily life activities. The “Cytokine Hypothesis of Depression” argues that MDD results from an imbalance between pro- and anti-inflammatory cytokines. Only 30% of patients with MDD respond to treatment with SSRI antidepressants.
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    Reinforcement Learning Predicts Response to SSRIs in Medication-Naïve Patients with Major Depressive Disorder
    (Al-Quds University, Deanship of Scientific Research, 2022-05-11) Yasmeen Sultan; Mahmud A. Sehwail; Mohammad M. Herzallah
    Background: Patients with major depressive disorder (MDD) exhibit hyposensitivity to positive reinforcement and hypersensitivity to negative reinforcement. In patients who respond to treatment, selective serotonin reuptake inhibitor (SSRI) antidepressants arguably modulate MDD symptoms by attenuating learning from negative reinforcement. However, only 30% of patients with MDD respond to antidepressants including SSRI. Cognitive differences between responders and non-responders were heretofore not investigated medication-naïve patients with MDD.
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    Using Dimensionality Reduction to Decode the Cognitive Correlates of Psychological Trauma in Patients with Post-Traumatic Stress Disorder
    (Al-Quds University, Deanship of Scientific Research, 2022-05-11) Abdallah Khaled Ahmed Ramadan; Ayman A. Salman; Oday M. Abushalbaq; Abdul-Rahman S. Sawalma; Mahmud A. Sehwail; Mohmmad M. Herzallah
    Background: Exposure to psychological trauma usually marks monumental changes in an individual’s clinical features, cognitive function, and underlying neural circuitry. A fraction of exposed individuals will develop subsequent post-raumatic stress disorder (PTSD). To date, there is no clear understanding of the cognitive consequences of exposure to psychological trauma, especially that which is related to PTSD. This could be attributed to the use of generic constructs to describe clinical features and cognitive function.