First Molecular Epidemiological Study of Cutaneous Leishmaniasis in Libya

dc.contributor.author Amro, Ahmad
dc.contributor.author Gashout, Aisha
dc.contributor.author Al-Dwibe, Hamida
dc.contributor.author Alam, Mohammad Zahangir
dc.contributor.author Annajar, Badereddin
dc.contributor.author Hamarsheh, Omar
dc.contributor.author Shubar, Hend
dc.contributor.other Schonian, Gabriele
dc.date.accessioned 2018-09-24T06:39:12Z
dc.date.available 2018-09-24T06:39:12Z
dc.date.issued 2012-06-19
dc.description.abstract Background: Cutaneous leishmaniasis (CL) is a major public health problem in Libya. The objective of this study was to investigate, for the first time, epidemiological features of CL outbreaks in Libya including molecular identification of parasites, the geographical distribution of cases and possible scenarios of parasite transmission. Methodology/Principal Findings: We studied 450 patients that came from 49 areas distributed in 12 districts in north-west Libya. The patients’ ages ranged from 9 months to 87 years (median age 25 years); 54% of the cases were males. Skin scrapings spotted on glass slides were collected for molecular identification of causative agent. The ribosomal internal transcribed spacer 1 (ITS1) was amplified and subsequently characterized by restriction fragment length polymorphism (RFLP) analysis. In total, 195 samples were successfully identified of which 148 (75.9%) were Leishmania major, and 47 (24.1%) Leishmania tropica. CL cases infected with L. major were found in all CL areas whereas L. tropica cases came mainly from Al Jabal Al Gharbi (46.4%), Misrata (17.8%) and Tarhuna districts (10.7%). A trend of seasonality was noticed for the infections with L. major which showed a clear peak between November and January, but was less pronounced for infections by L. tropica. Conclusion: The first molecular study on CL in Libya revealed that the disease is caused by L. major and L. tropica and the epidemiological patterns in the different foci were the same as in other Mediterranean foci of CL. en_US
dc.description.sponsorship The authors have no support or funding to report. en_US
dc.identifier.citation Amro A, Gashout A, Al-Dwibe H, Zahangir Alam M, Annajar B, et al. (2012) First Molecular Epidemiological Study of Cutaneous Leishmaniasis in Libya. PLoS Negl Trop Dis 6(6): e1700. doi:10.1371/journal.pntd.0001700 en_US
dc.identifier.issn 1935-2735
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/983
dc.language.iso en_US en_US
dc.publisher PLOS en_US
dc.title First Molecular Epidemiological Study of Cutaneous Leishmaniasis in Libya en_US
dc.type Article en_US
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