Extent and nature of unlicensed and off-label medicine use in hospitalized children in Palestine

dc.contributor.author Hussein Hallak
dc.contributor.author Maher khdour
dc.contributor.author Alayasa, Kawther
dc.contributor.author AlShahed, Qusai
dc.contributor.author Hawwa, Ahmed
dc.contributor.author McElnay, James
dc.date.accessioned 2018-08-16T04:17:54Z
dc.date.available 2018-08-16T04:17:54Z
dc.date.issued 2011-05-13
dc.description.abstract Objective of the study To determine the extent and nature of unlicensed/off-label prescribing patterns in hospitalised children in Palestine. Setting Four paediatric wards in two public health system hospitals in Palestine [Caritas children’s hospital (Medical and neonatal intensive care units) and Rafidia general hospital (Medical and surgical units)]. Method A prospective survey of drugs administered to infants and children \18 years old was carried out over a five-week period in the four paediatric wards. Main outcome measure Drug-licensing status of all prescriptions was determined according to the Palestinian Registered Product List and the Physician’s Desk Reference. Results Overall, 917 drug prescriptions were administered to 387children. Of all drug prescriptions, 528 (57.5%) were licensed for use in children; 65 (7.1%) were unlicensed; and 324 (35.3%) were used off-label. Of all children, 49.6% received off-label prescriptions, 10.1% received unlicensed medications and 8.2% received both. Seventy-two percent of off-label drugs and 66% of unlicensed drugs were prescribed for children \2 years. Multivariate analysis showed that patients who were admitted to the neonatal intensive care unit and infants aged 0–1 years were most likely to receive a greater number of off-label or unlicensed medications (OR 1.80; 95% CI 1.03–3.59 and OR 1.99; 95% CI 0.88–3.73, respectively). Conclusion The present findings confirmed the elevated prevalence of unlicensed and off-label paediatric drugs use in Palestine and strongly support the need to perform well designed clinical studies in children. en_US
dc.description.sponsorship The authors wish to thank Dr Chris Cardwell, Department of Epidemiology and Public Health, Queen’s University Belfast, for his statistical support, Nursing & administrative staff at the Caritas and Rafidia hospitals. The Daniel Turnberg UK/Middle East Travel Fellowship for financial support is acknowledged en_US
dc.identifier.issn 2210-7703
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/736
dc.language.iso en_US en_US
dc.publisher Springer en_US
dc.subject Neonates en_US
dc.subject Off-label prescribing en_US
dc.subject Paediatrics en_US
dc.subject Palestine en_US
dc.subject Unlicensed medicines en_US
dc.subject Ward en_US
dc.title Extent and nature of unlicensed and off-label medicine use in hospitalized children in Palestine en_US
dc.type Article en_US
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