Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study
Date
2006-01-01
Authors
El-Sharif N
Douwes J
Hoet P
Nemery B.
Journal Title
Journal ISSN
Volume Title
Publisher
J Asthma
Abstract
This study was carried out to evaluate the relationship between wheezing or sensitization and concentrations of mites, cat and dog allergens, and
bacterial endotoxin in Palestine.Anested case-control involved analysis of mattress and floor dust from a 110 children’s houses with reported wheezing
and without wheezing. We found no consistent associations between allergen levels and either wheeze or specific atopic sensitization. Furthermore,
no clear associations between mattress endotoxin levels and wheeze or atopy were found. Endotoxin in floor dust was inversely associated with atopic
sensitization and wheeze, statistically significant only for atopic wheeze. Finally, a nonsignificant inverse association was observed between living
room endotoxin and atopy within the non-wheezing control group. In conclusion, although our study found mostly negative results, it does suggest
that endotoxin on living room floors might protect against atopic wheeze. However, this finding should be interpreted with caution due the relatively
small sample size of the study and requires further confirmation.
Description
Keywords
Citation
8. El-Sharif N, Douwes J, Hoet P, Nemery B. Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study. J Asthma. 2006 Apr;43(3):241-7. doi: 10.1080/02770900600567122. PMID: 16754529.