Can environment or allergy explain international variation in prevalence of wheeze in childhood?

dc.contributor.authorWeinmayr G
dc.contributor.authorJaensch A
dc.contributor.authorRuelius AK
dc.contributor.authorForastiere F
dc.contributor.authorStrachan DP
dc.contributor.authorISAAC Phase Two Study Group.
dc.date.accessioned2024-11-28T14:07:43Z
dc.date.available2024-11-28T14:07:43Z
dc.date.issued2019-05-01
dc.description.abstractAsthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8-12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in the prevalence of recent wheeze. Adjustment for single individual-level risk factors changed the centre-level variation from a reduction of up to 8.4% (and 8.5% for atopy) to an increase of up to 6.8%. Modeling the 11 most influential environmental factors among all children simultaneously, the centre-level variation changed little overall (2.4% increase). Modelling only factors that decreased the variance, the 6 most influential factors (synthetic and feather quilt, mother's smoking, heating stoves, dampness and foam pillows) in combination resulted in a 21% reduction in variance. Ecological (centre-level) risk factors generally explained higher proportions of the variation than did individual risk factors. Single environmental factors and aeroallergen sensitisation measured at the individual (child) level did not explain much of the between-center variation in wheeze prevalence.
dc.identifier.citationWeinmayr G, Jaensch A, Ruelius AK, Forastiere F, Strachan DP; ISAAC Phase Two Study Group. Can environment or allergy explain international variation in prevalence of wheeze in childhood? Eur J Epidemiol. 2019 May;34(5):509-520. https://doi. 10.1007/s10654-018-0463-z. Epub 2018 Nov 11. PMID: 30415436.
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/9547
dc.language.isoen_US
dc.publisherEur J Epidemiol
dc.titleCan environment or allergy explain international variation in prevalence of wheeze in childhood?
dc.typeArticle
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