Identification of key components in water extracts of tea (Camellia Sinensis) using UPLC-PDA-ESi- MS and evaluation of their possible antimalarial properties

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dc.contributor.authorMutaz Akkawi
dc.contributor.authorSaleh Abu-Lafi
dc.contributor.authorQassem Abu-Remeleh
dc.date.accessioned2024-06-24T07:02:34Z
dc.date.available2024-06-24T07:02:34Z
dc.date.issued2023-10-31
dc.description.abstractThis study used a semi-quantitative approach to examine how water extracted green and black tea (Camellia Sinensis) inhibits the formation of β-hematin in-vitro. LC-PDA-ESi-MS analysis of the tea extracts revealed that they contain many active catechins. When compared to the positive control, chloroquine, the results demonstrated that black water extracts had a considerable anti-malarial potential even at significantly lower dosages, while the green tea water extracts showed no effect. However, when a bicarbonate solution was used to create the green tea infusion, the result was similarly effective to the positive control. Additionally, there was no difference in β-hematin formation when the black tea was prepared at various time points (freshly prepared vs. 24-48 hours of incubation). The absence of time-dependent effects suggests that the in-vitro assay is unaffected by oxidation or any other changes that may have occurred in the extracts and solely reacts to stable active compounds or minerals that prevent β-hematin formation. The diverse combined catechins present in the tea extracts were efficient in forming a favorable complex with free heme, thereby preventing β-hematin formation, which could irreversibly harm the plasmodium parasite during the intraerythrocytic stage.
dc.description.sponsorshipAcknowledgments: None.
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/9277
dc.language.isoen
dc.publisherMedCrave
dc.titleIdentification of key components in water extracts of tea (Camellia Sinensis) using UPLC-PDA-ESi- MS and evaluation of their possible antimalarial properties
dc.typeArticle
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