Computationally Designed Enzyme Models to Replace Natural Enzymes in Prodrug Approaches
Date
2012-11-16
Authors
Karaman, Rafik
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Abstract
The striking efficiency of enzyme catalysis has inspired many
organic chemists to explore enzyme mechanisms by studying certain
intra molecular processes such as enzyme models which proceed faster
than their intermolecular counterparts. This research brings about the
important question of whether enzyme models will replace natural
enzymes in the conversion of prodrugs to their parental drugs.
Enzymes are mandatory for the inter conversion of many prodrugs
to their parental drugs. Among the most important enzymes in the
bioconversion of prodrugs are amides (ex. trypsin, chymotrypsin,
elastase, carboxypeptidase, and aminopeptidase) and ester-based
prodrugs (ex. paraoxonase, carboxylesterase, acetylcholinesterase
and cholinesterase). Most of these enzymes are hydrolytic enzymes,
however, non-hydrolytic enzymes, including all cytochrome P450
enzymes, are also capable of catalyzing the bioconversion of ester and
amide-based prodrugs [1].
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Citation
Karaman R (2013) Computationally Designed Enzyme Models to Replace Natural Enzymes in Prodrug Approaches. Drug Des 2: e111. doi:10.4172/2169- 0138.1000e111