Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years

dc.contributor.authorNajjar, Anas
dc.contributor.authorNajjar, Abderrahman
dc.contributor.authorKaraman, Rafik
dc.date.accessioned2020-07-21T10:35:21Z
dc.date.available2020-07-21T10:35:21Z
dc.date.issued2020-02-17
dc.description.abstractBackground: The design and development of prodrugs is the most common and e ective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs. A respected number of prodrugs have been reached the drugs market throughout history and the recent years have witnessed a significant increase in the use of prodrugs as a replacement of their parent drugs for an e cient treatment of various ailment. Methods: A Scan conducted to find recent approved prodrugs and prodrugs in development. Results: Selected prodrugs were reported and categorized in accordance to their target systems. Conclusions: the prodrug approach has shown many successes and still remains a viable and e ective approach to deliver new active agents. This conclusion is supported by the recent approved prodrugs and the scan of clinical trials conducted between 2013–2018.en_US
dc.description.sponsorshipFunding: This research received no external funding. Acknowledgments: The authors would like to thank Al-Quds University-Scientific Research O ce for covering the publication fees for this review article.en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5700
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectACT-281959en_US
dc.subjectANAVEX 2-73en_US
dc.subjectbaloxavir marboxilen_US
dc.subjectclinical trialen_US
dc.subjectevofosfamideen_US
dc.subjectfostemsaviren_US
dc.subjectixazomiben_US
dc.subjectpretomaniden_US
dc.subjectprodrugen_US
dc.subjectselexipagen_US
dc.titleNewly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Yearsen_US
dc.typeArticleen_US
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