Efficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic acid

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dc.contributor.authorKhalaf, Samer
dc.contributor.authorAl-Rimawi, Fuad
dc.contributor.authorKhamis, Mustafa
dc.contributor.authorNir, Shlomo
dc.contributor.authorBufo, Sabino A.
dc.contributor.authorScrano, Laura
dc.contributor.authorMecca, Gennaro
dc.contributor.authorKaraman, Rafik
dc.date.accessioned2020-02-23T20:04:31Z
dc.date.available2020-02-23T20:04:31Z
dc.date.issued2013-08-15
dc.description.abstractThe efficiency of sequential advanced membrane technology wastewater treatment plant towards removal of a widely used non-steroid anti-inflammatory drug (NSAID) mefenamic acid was investigated. The sequential system included activated sludge, ultrafiltration by hollow fibre membranes with 100 kDa cutoff, and spiral wound membranes with 20 kDa cutoff, activated carbon and a reverse osmosis (RO) unit. The performance of the integrated plant showed complete removal of mefenamic acid from spiked wastewater samples. The activated carbon column was the most effective component in removing mefenamic acid with a removal efficiency of 97.2%. Stability study of mefenamic acid in pure water and Al-Quds activated sludge revealed that the anti-inflammatory drug was resistant to degradation in both environments. Batch adsorption of mefenamic acid by activated charcoal and a composite micelle (otadecyltrimethylammonium (ODTMA)–clay (montmorillonite) was determined at 25.0◦C. Langmuir isotherm was found to fit the data with Qmax of 90.9 mg g−1 and 100.0 mg g−1 for activated carbon and micelle-clay complex, respectively. Filtration experiment bymicelle-clay columnsmixed with sand in themg L−1 range revealed complete removal of the drug with much larger capacity than activated carbon column. The combined results demonstrated that an integration of a micelle-clay column in the plant system has a good potential to improve the removal efficiency of the plant towards NSAID drugs such as mefenamic acid.en_US
dc.description.sponsorshipBir-zeit Pharmaceutical Co. is thanked for the supply of mefenamic acid. This work was supported by the European Commission in the framework of the Project ‘Diffusion of nanotechnology based devices for water treatment and recycling - NANOWAT’ (ENPI CBC MED I-B/2.1/049, Grant No. 7/1997).en_US
dc.identifier.citationSamer Khalaf , Fuad Al-Rimawi , Mustafa Khamis , Shlomo Nir , Sabino A. Bufo , Laura Scrano , Gennaro Mecca & Rafik Karaman (2013) Efficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic acid, Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering, 48:13, 1655-1662en_US
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5087
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectAnti-inflammatory drugsen_US
dc.subjectwastewateren_US
dc.subjectmembrane technologyen_US
dc.subjectactivated carbonen_US
dc.subjectmicelle-clay complexen_US
dc.subjectadsorption isothermsen_US
dc.subjectmefenamic aciden_US
dc.titleEfficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic aciden_US
dc.typeArticleen_US
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