Effect of Erythropoietin on Haematological Parameters in Chronic Renal Failure Patients Undergoing Dialysis in Malaysia

Date
2014-10-03
Authors
Elmi, Omar Salad
Ghrayeb, Farid AW
Meng, Ong Loke
Nadiah, Wan-Arfah
Noushad, Mohammed
Kaur, Gurjeet
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Abstract
Background: The worldwide rise in the number of patients with chronic renal failure (CRF). Chronic Renal Failure is a major health problem resulting in considerable increase in mortality and morbidity, decreased quality of life and heavy cost of therapies. . Objective: This study aims to evaluate the haematological parameters and iron status during monitoring of Chronic Renal Failure patients and to study the effects of subcutaneously and intravenously administered erythropoietin (EPO) in treating anaemia in Chronic Renal Failure patients. Methods: A retrospective record review study was conducted among the CRF patients treated at Hospital Pulau Pinang between 2005 and 2009. A total of 45 patients were randomly selected by using simple random sampling. The parameters were taken one to two weeks prior to EPO treatment and at 1 month and 3 months after EPO therapy was started. Data analyses were performed by using paired t test and independent t test via SPSS Version. 18.0.0. Results: After one month post-EPO, there was a significant difference of mean serum iron between continuous ambulatory peritoneal dialysis (CAPD) and haemodialysis groups where the mean value of serum iron was higher in CAPD group. After three months post-EPO, there were significant differences of mean white blood cells and serum iron between the two groups. Conclusions: Chronic renal failure patients undergoing dialysis responded to EPO treatment and subcutaneous EPO administration appeared to give more favourable results compared to intravenous EPO.
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Keywords
anaemia, chronic renal failure, dialysis, erythropoietin, haematological parameters, Malaysia
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