العوامل الغذائية ومخاطرها على الإصابة بمرض الورم الليمفاوي غير الهودجكن بين الفلسطينيين
Date
2015-09-12
Authors
مرام محمد شاكر دحدول
maram mohammed shaker dahdol
Journal Title
Journal ISSN
Volume Title
Publisher
AL-Quds University
جامعة القدس
جامعة القدس
Abstract
Background: The incidence of Non-Hodgkin Lymphoma (NHL) increased worldwide
during the second half of the last century and then stabilized during the nineties but
subsequently increased. Environmental factors and dietary habits have been reported to
play an important role in the etiology of NHL by influencing the immune system.
However, no such data are available from Palestine.
Objectives: To participate in establishing a platform to study B-NHL in Palestine and
further to examine the association between dietary factors and the risk of B-NHL among
Palestinian B-NHL patients versus controls.
Design: Case-control study.
Methods: A case-control study was conducted between 2009-2013 including 306-
histological confirmed B-NHL cases and 392 cancer-free controls among adult Palestinians
recruited from three major Palestinian hospitals in the West Bank and Jerusalem which
have an oncology department in addition to Hadassah Hospital in West Jerusalem. In the
primary study analysis, an imbalance was encountered in the regional distribution of cases
and controls in the central area. In order to correct for this imbalance, I recruited 71
controls from the primary health care centers in Jericho, Ramallah and Al-Azaria on the
basis of frequency matched case-control study in terms of age and gender and region. The
study participants were administered a questionnaire which is based on the international
Epi-Lymph questionnaire, which focuses on demographic characteristics, types of
environmental exposure and on diet and nutritional intake, specifically meat, milk, dairy,vegetables and fruits. Blood samples were also collected from participants for the purpose
of DNA purification and viral serology testing.
The overall data-base was used to study the association between nutritional factors and the
risk of NHL. The data was analyzed by Statistical Package for the SocialSciences(SPSS)and associations were examined by multivariate logistic regression. For
food intake analysis, the median value for each food group was calculated from overall
distribution of the study population in order to use the value below the median as a
reference value to detect associations by logistic regression.
Results: High consumption of meat (OR=1.8; 95% CI: 0.8-4.3) and milk (OR=1.3; 95%
CI: 0.7-2.6) was found to be positively associated with the risk of B-NHL. Vegetable
intake was also positively associated with the risk of B-NHL (OR=1.3; 95% CI: 0.4-4).
Similarly, dairy products were significantly associated with an increased risk of B-NHL
(OR=2.3; 95% CI: 1.2-4.4). In contrast, a significantly inverse association was encountered
between fish consumption and B-NHL risk (OR=0.4; 95% CI: 0.2-0.8), and an inverse
association was found between the consumption of fruits and B-NHL risk (OR=0.7; 95%
CI: 0.2-2.1).
Conclusion:The results of this study showed that dietary intake may affect the risk of NHL
as positive associations were found with meat, milk, dairy products and vegetables
consumption, while an inverse association with fish and fruits consumption was
encountered.
Keywords: dietary factors, non-Hodgkin lymphoma, case–control study, Palestine.
Description
Keywords
السياسات والاداره الصحية , Policies & Health Management