Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract

dc.contributor.authorQabaha, Khaled
dc.contributor.authorAL-Rimawi, Fuad
dc.contributor.authorQasem, Ahmad
dc.contributor.authorNaser, Saleh A.
dc.date.accessioned2020-02-23T19:51:21Z
dc.date.available2020-02-23T19:51:21Z
dc.date.issued2017-08-17
dc.description.abstractOlive leaves are rich in polyphenolic compounds that are known to have antioxidant, antimicrobial, and antiinflammatory activities. Therefore, olive leaf extract (OLE) is considered as a natural supplement. In this study we evaluated the antibacterial and the anti-inflammatory effect of OLE and its individual phenolic components in vitro. Polymorphonuclear cells (PMNCs) were isolated from the whole blood using Histopaque solution and cultured in RPMI-enriched medium. Tumor necrosis factor a (TNFa) level was determined by ELISA after 24 h of lipopolysaccharide stimulation. The antibacterial activity of OLE was determined by well diffusion assay. We found a significant decrease in TNFa secretion level in PMNCs culture treated with OLE. Oleuropein is the only OLE component that has shown anti-inflammatory effects at a concentration of 20 lg/mL. Furthermore, OLE exhibited antibacterial activity against some gram positive bacterial strains; however, gram negative bacterial strains were resistant to OLE. Downregulation of TNFa secretion in PMNCs culture in response to OLE treatment indicates that this polyphenol-rich extract has an anti-inflammatory effect, and oleuropein is the major OLE component responsible for this effect. The antibacterial activity of OLE is limited to gram positive bacteria.en_US
dc.description.sponsorshipOur thanks are due to all laboratory members who participated in this study.en_US
dc.identifier.citationTY - JOUR AU - Qabaha, Khaled AU - Al-Rimawi, Fuad AU - Qasem, Ahmad AU - Naser, Saleh PY - 2017/11/03 SP - T1 - Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract VL - 21 DO - 10.1089/jmf.2017.0070 JO - Journal of Medicinal Food ER -en_US
dc.identifier.issn1096-620X
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5076
dc.language.isoenen_US
dc.subjectgallic aciden_US
dc.subjectOLEen_US
dc.subjectoleuropeinen_US
dc.subjectolive leaf extracten_US
dc.subjectphenolic compoundsen_US
dc.subjectTNFaen_US
dc.titleOleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extracten_US
dc.typeArticleen_US
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