Homology modeling, molecular dynamics and docking simulations of rat A2A receptor: a three-dimensional model validation under QSAR studies

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dc.contributor.authorSoriano-Ursua, Marvin A
dc.contributor.authorDeeb, Omar
dc.contributor.authorSegura-Cabrera, Aldo
dc.contributor.authorCorrea-Basurto, Jose
dc.date.accessioned2018-08-19T19:26:27Z
dc.date.available2018-08-19T19:26:27Z
dc.date.issued2013-12-17
dc.description.abstractUnderstanding the three-dimensional structure (3-D) of GPCRs (G protein coupled receptors) can aid in the design of applicable compounds for the treatment of several human disorders. To this end, several 3-D models have been obtained in recent years. In this work, we have built the rat adenosine receptor model (rA2AR) by employing computational tools. First, the 3-D rA2AR model was built by homology modeling using the human adenosine receptor (hA2AR) structure (PDB codes: 3EML) as a template. Then, the rA2AR model was refined by molecular dynamics simulations, in which the initial and refined 3-D structures were used for molecular docking simulations and Quantitative structure-activity relationship (QSAR) studies using a set of known experimentally tested ligands to validate this rA2AR model. The results showed that the hindrance effect caused by ribose attached to agonists play an important role in activating the receptor via formation of several hydrogen bonds. In contrast, the lack of this moiety allows blocking of the receptor. The theoretical affinity estimation shows good correlation with reported experimental data. Therefore, this work represents a good example for getting reliable GPCR models under computational procedures.en_US
dc.description.sponsorshipWe are grateful for the scholarships and financial support from CONACYT, México (132353), ICyTDF (PIRIVI09-9), COFAA and SIP-IPN (20110786), PAPIIT-DGAPA UNAM-215708 and Posgrado en Ciencias Biológicas UNAM. The authors thank the Centro Nacional de Supercomputo, México, for providing access to the “Argentum” cluster.en_US
dc.identifier.issn0973-0532
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/766
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectA2A adenosine receptoren_US
dc.subjecthomology modelingen_US
dc.subjectxanthineen_US
dc.subjectdrug developmenten_US
dc.subjectrat brainen_US
dc.subjectParkinson’s diseaseen_US
dc.titleHomology modeling, molecular dynamics and docking simulations of rat A2A receptor: a three-dimensional model validation under QSAR studiesen_US
dc.typeArticleen_US
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