Anticancer, antibacterial, and antifungal activities of arum palaestinum plant extracts
Files
Date
2017-10-20
Authors
Naseef, Hani
Qadadha, Heba
Abu Asfour, Yara
Sabri, Israr
Al-Rimawi, Fuad
Abu-Qatouseh, Luay
Farraj, Mohammad
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Traditional natural remedies have long played an important role in the
treatment of cancer and infectious diseases. A part from the high cost
and undesirable side effects associated with synthetic drugs, increased
interest has intensified to determine the biological effects of plant
extracts on malignant cells as alternative for conventional drugs used
in the markets. The medicinal properties of Arum Palaestinum Boiss
were in-vitro investigated in this research project. Arum palaestinum is
chosen based on its use in traditional palestinian herbal medicine. The
leaves of this plant were air dried in the shade and then three types of
extract were obtained and their antimicrobial and for anticancer
activity testing. Investigations on three different cancer cell lines
(C2Cl2, 3T3-L1, Hela) revealed direct inhibitory effect of the extracts.
This effect differs according to concentrations used. Aqueous boiled extract was more
effective at lower extract concentrations as compared to other two extracts. Arum
palaestinum plant extracts showed no inhibitory effect on bacterial species (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa) as well as yeasts (Candida albicans). In conclusion, Arum palaestinum has potentially anticancer effect. Further investigations are required to confirm this conclusion and to elucidate the mechanisms of actions and toxicity of this herb.
Description
Keywords
Arum Palaestinum , anticancer , herbal medicine , crude extract