The clinical burden of human cystic echinococcosis in Palestine, 2010-2015

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dc.contributor.authorAl-Jawabreh, Amer
dc.contributor.authorEreqat, Suheir
dc.contributor.authorDumaidi, Kamal
dc.contributor.authorNasereddin, Abdelmajeed
dc.contributor.authorAl-Jawabreh, Hanan
dc.contributor.authorAzmi, Kifaya
dc.contributor.authorAl-Laham, Nahed
dc.contributor.authorNairat, Moath
dc.contributor.authorCasulli, Adriano
dc.contributor.authorMaqboul, Husni
dc.contributor.authorAbdeen, Ziad
dc.date.accessioned2019-12-18T11:58:36Z
dc.date.available2019-12-18T11:58:36Z
dc.date.issued2017-07-03
dc.description.abstractBackground Cystic echinococcosis (CE) is classified by the WHO as a neglected disease inflicting economic losses on the health systems of many countries worldwide. The aim of this caseseries study was to investigate the burden of human CE in Palestine during the period between 2010 and 2015. Methodology/Principal findings Records of surgically confirmed CE patients from 13 public and private hospitals in the West Bank and Gaza Strip were reviewed. Patients' cysts were collected from surgical wards and formalin-fixed paraffin-embedded (FFPE) blocks were collected from histopathology departments. Molecular identification of CE species /genotypes was conducted by targeting a repeat DNA sequence (EgG1 Hae III) within Echinococcus nuclear genome and a fragment within the mitochondrial cytochrome c oxidase subunit 1, (CO1). Confirmation of CE species/genotypes was carried out using sequencing followed by BLAST analysis and the construction of maximum likelihood consensus dendrogram. CE cases were map-spotted and statistically significant foci identified by spatial analysis. A total of 353 CE patients were identified in 108 localities from the West Bank and Gaza Strip. The average surgical incidence in the West Bank was 2.1 per 100,000. Spot-mapping and purely spatial analysis showed 13 out of 16 Palestinian districts had cases of CE, of which 9 were in the West Bank and 4 in Gaza Strip. Al-Khalil and Bethlehem were statistically significant foci of CE in Palestine with a six-year average incidence of 4.2 and 3.7 per 100,000, respectively. Conclusions/Significance To the best of our knowledge, this is the first confirmation of human CE causative agent in Palestine. This study revealed that E. granulosus sensu stricto (s.s.) was the predominating species responsible for CE in humans with 11 samples identified as G1 genotype and 2 as G3 genotype. This study emphasizes the need for a stringent surveillance system and risk assessment studies in the rural areas of high incidence as a prerequisite for control measures.en_US
dc.description.sponsorshipThe research that has led to these results has been technically supported by the European Community's Seventh Framework Programme under the grant agreement 602051 (Project HERACLES: Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies; http://www. Heracles-fp7.eu/).en_US
dc.identifier.citationAl-Jawabreh A, Ereqat S, Dumaidi K, Nasereddin A, Al-Jawabreh H, Azmi K, et al. (2017) The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. PLoS Negl Trop Dis 11(7): e0005717.en_US
dc.identifier.issn1935-2735
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5039
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.titleThe clinical burden of human cystic echinococcosis in Palestine, 2010-2015en_US
dc.typeArticleen_US
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