Antibacterial Predrugs-from 1899 till 2015

dc.contributor.author Elayyan, Sabrin
dc.contributor.author Karaman, Donia
dc.contributor.author Mecca, Gennaro
dc.contributor.author Scrano, Laura
dc.contributor.author Bufo, Sabino A.
dc.contributor.author Karaman, Rafik
dc.date.accessioned 2018-09-16T08:40:23Z
dc.date.available 2018-09-16T08:40:23Z
dc.date.issued 2015-07-08
dc.description.abstract The predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug strategy has been extensively developed to solve many unwanted drug properties. This approach has several advantages over conventional drug administration and it has the potential to be quite effective method for the treatment of diseases in the future. In this mini-review we describe a number of antibacterial agents‘ predrugs, and the ways by which predrug strategy was exploited to overcome many pharmaceutical and pharmacokinetic problems that the parent active antibacterial drugs suffer from such as, low bioavailability by increasing or decreasing lipophilicity, site selectivity for higher absorption and less toxicity, short duration of action to increase patient compliance, rapid metabolism to increase oral bioavailability and masking bitter sensation which is crucial for geriatric and pediatric patient compliance. en_US
dc.identifier.issn 2278 – 4357
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/920
dc.language.iso en_US en_US
dc.publisher WJPPS,Dr. T Pal en_US
dc.subject Predrugs en_US
dc.subject Prodrugs en_US
dc.subject Antibacterials predrugs en_US
dc.subject Antibacterial agents en_US
dc.subject Predrug chemical approach en_US
dc.subject Intramolecular process en_US
dc.subject Bitter sensation en_US
dc.title Antibacterial Predrugs-from 1899 till 2015 en_US
dc.type Article en_US
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