Prevalence of Hemophilia A and B: Molecular and Clinical Similarities and Differences
Hiba abu sharkh
Shadia Al Najar
Al-Quds University - Deanship of Scientific Research
Background: Hemophilia A and B are rare congenital disorders linked to the X chromosome due to a lack or deficiency of clotting factor VIII (FVIII) or factor IX (FIX), respectively. The severity of the disease depends on decreased levels of factor VIII or factor IX, which are determined by the type of causative mutation in the gene coding factors (F8 and F9, respectively), and this can lead to spontaneous bleeding, as well as bleeding after injuries or surgery, given the importance of hemophilia. The old and recent studies aimed at identifying the disease and making society aware of it. Despite this, the Palestinian society lacks local awareness of this disease.