Comprehensive Review on Alzheimer’s Disease: Causes and Treatment Breijyeh, Zeinab Karaman, Rafik 2020-12-21T17:26:32Z 2020-12-21T17:26:32Z 2020-12-08
dc.description.abstract Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypotheses. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease. Currently, there are only two classes of approved drugs to treat AD, including inhibitors to cholinesterase enzyme and antagonists to Nmethyl D-aspartate (NMDA), which are effective only in treating the symptoms of AD, but do not cure or prevent the disease. Nowadays, the research is focusing on understanding AD pathology by targeting several mechanisms, such as abnormal tau protein metabolism, β-amyloid, inflammatory response, and cholinergic and free radical damage, aiming to develop successful treatments that are capable of stopping or modifying the course of AD. This review discusses currently available drugs and future theories for the development of new therapies for AD, such as disease-modifying therapeutics (DMT), chaperones, and natural compounds. en_US
dc.identifier.issn 1420-3049
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject Alzheimer’s disease en_US
dc.subject neurodegeneration en_US
dc.subject β-amyloid peptide en_US
dc.subject tau protein en_US
dc.subject risk factors en_US
dc.subject disease-modifying therapy en_US
dc.subject chaperons en_US
dc.subject heat shock proteins en_US
dc.title Comprehensive Review on Alzheimer’s Disease: Causes and Treatment en_US
dc.type Article en_US
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