Association of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine

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dc.contributor.authorMohammad Abdelhafez
dc.contributor.authorAbedelmajeed Nasereddin
dc.contributor.authorOmar Abu Shamma
dc.contributor.authorRajaa Abed
dc.contributor.authorRaghida Sinnokrot
dc.contributor.authorOmar Marof
dc.contributor.authorTariq Heif
dc.contributor.authorZaid Erekat
dc.contributor.authorAmer Al-Jawabreh
dc.contributor.authorSuheir Ereqat
dc.date.accessioned2024-06-24T06:43:31Z
dc.date.available2024-06-24T06:43:31Z
dc.date.issued2023-09-16
dc.description.abstractThe clinical course and severity of COVID-19 vary among patients. Tis study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor (IFNAR2) rs2236757 and oligoadenylate synthetase 3 (OAS3) rs10735079 with the risk of COVID-19 infection and its severity among Palestinian patients. Te study was conducted between April and May 2021 on 154 participants who were divided into three groups: the control group (RT-PCR-negative, n = 52), the community cases group (RT-PCR-positive, n = 70), and the critically ill cases (ICU group; n = 32). Te genotyping of the investigated polymorphisms was performed using amplicon-based next-generation sequencing. Te genotypes distribution for the IFNAR2 rs2236757 was signifcantly diferent among the study groups (P = 0.001), while no statistically signifcant diferences were found in the distribution of genotypes for the OAS3 rs10735079 (P = 0.091). Logistic regression analysis adjusted for possible confounding factors revealed a signifcant association between the risk allele rs2236757A and critical COVID-19 illness (P < 0.025). Among all patients, those who carried the rs2236757GA were more likely to have a sore throat (OR, 2.52 (95% CI 1.02–6.24); P = 0.011); the presence of the risk allele rs2236757A was associated with an increased risk to dyspnea (OR, 4.70 (95% CI 1.80-12.27); P < 0.001), while the rs10735079A carriers were less likely to develop muscle aches (OR, 0.34 (95% CI 0.13–0.88); P = 0.0248) and sore throat (OR, 0.17 (95% CI 0.05–0.55); P < 0.001). In conclusion, our results revealed that the rs2236757A variant was associated with critical COVID-19 illness and dyspnea, whereas the rs10735079A variant was protective for muscle aches and sore throat
dc.description.sponsorshipTe authors would like to thank all the study participants.
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/9275
dc.publisherHindawi
dc.titleAssociation of IFNAR2 rs2236757 and OAS3 rs10735079 Polymorphisms with Susceptibility to COVID-19 Infection and Severity in Palestine
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