Dissociating the Cognitive Effects of Levodopa versus Dopamine Agonists in aNeurocomputational Model of Learning in Parkinson's Disease

dc.contributor.author Moustafa, Ahmed A.
dc.contributor.author Herzallah, Mohammad M.
dc.contributor.author Gluck, Mark A.
dc.date.accessioned 2018-09-23T09:39:20Z
dc.date.available 2018-09-23T09:39:20Z
dc.date.issued 2012-11-01
dc.description.abstract Background/Aims: Levodopa and dopamine agonists have different effects on the motor, cognitive, and psychiatric aspects of Parkinson’s disease (PD). Methods: Using a computational model of basal ganglia (BG) and prefrontal cortex (PFC) dopamine, we provide a theoretical synthesis of the dissociable effects of these dopaminergic medications on brain and cognition. Our model incorporates the findings that levodopa is converted by dopamine cells into dopamine, and thus activates prefrontal and striatal D 1 and D 2 dopamine receptors, whereas antiparkinsonian dopamine agonists directly stimulate D 2 receptors in the BG and PFC (although some have weak affinity to D 1 receptors). Results: In agreement with prior neuropsychological studies, our model explains how levodopa enhances, but dopamine agonists impair or have no effect on, stimulus-response learning and working memory. Conclusion: Our model explains how levodopa and dopamine agonists have differential effects on motor and cognitive processes in PD. en_US
dc.identifier.issn 1660-2862
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/975
dc.language.iso en_US en_US
dc.publisher Karger AG, Basel en_US
dc.subject Basal ganglia en_US
dc.subject Dopamine agonists en_US
dc.subject Levodopa en_US
dc.subject Parkinson’s disease en_US
dc.subject Prefrontal cortex en_US
dc.subject Reinforcement en_US
dc.subject Stimulus-response learning en_US
dc.subject Working memory en_US
dc.title Dissociating the Cognitive Effects of Levodopa versus Dopamine Agonists in aNeurocomputational Model of Learning in Parkinson's Disease en_US
dc.type Article en_US
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