Dissociating the Cognitive Effects of Levodopa versus Dopamine Agonists in aNeurocomputational Model of Learning in Parkinson's Disease

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dc.contributor.authorMoustafa, Ahmed A.
dc.contributor.authorHerzallah, Mohammad M.
dc.contributor.authorGluck, Mark A.
dc.date.accessioned2018-09-23T09:39:20Z
dc.date.available2018-09-23T09:39:20Z
dc.date.issued2012-11-01
dc.description.abstractBackground/Aims: Levodopa and dopamine agonists have different effects on the motor, cognitive, and psychiatric aspects of Parkinson’s disease (PD). Methods: Using a computational model of basal ganglia (BG) and prefrontal cortex (PFC) dopamine, we provide a theoretical synthesis of the dissociable effects of these dopaminergic medications on brain and cognition. Our model incorporates the findings that levodopa is converted by dopamine cells into dopamine, and thus activates prefrontal and striatal D 1 and D 2 dopamine receptors, whereas antiparkinsonian dopamine agonists directly stimulate D 2 receptors in the BG and PFC (although some have weak affinity to D 1 receptors). Results: In agreement with prior neuropsychological studies, our model explains how levodopa enhances, but dopamine agonists impair or have no effect on, stimulus-response learning and working memory. Conclusion: Our model explains how levodopa and dopamine agonists have differential effects on motor and cognitive processes in PD.en_US
dc.identifier.issn1660-2862
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/975
dc.language.isoen_USen_US
dc.publisherKarger AG, Baselen_US
dc.subjectBasal gangliaen_US
dc.subjectDopamine agonistsen_US
dc.subjectLevodopaen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectPrefrontal cortexen_US
dc.subjectReinforcementen_US
dc.subjectStimulus-response learningen_US
dc.subjectWorking memoryen_US
dc.titleDissociating the Cognitive Effects of Levodopa versus Dopamine Agonists in aNeurocomputational Model of Learning in Parkinson's Diseaseen_US
dc.typeArticleen_US
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